Research Article | Volume: 2 Issue: 10, October, 2012

Evaluation of biochemical indices following administration of artemether, halofantrine and a combination of artemether and lumefantrine in guinea pigs

J.S. Aprioku and A.W. Obianime   

Open Access    DOI: 10.7324/JAPS.2012.21011

Abstract

Combination of artemether and lumefantrine (artemether-lumefantrine) is an orally effective artemisinin-based combination therapy, used widely in the treatment of Plasmodium falciparum infections. The present study investigates the comparative effects of artemether, halofantrine and artemether-lumefantrine on biochemical indices in the male guinea pig. Half, normal and double therapeutic doses of the drugs were given to different groups of animals (n=5) by oral gavage. After the drug treatments, serum levels of biochemical parameters were measured using standard methods. Artemether significantly (p


Keyword:     ACTsartemether-lumefantrinebiochemicalhalofantrinelumefantrine


Citation:

J.S. Aprioku and A.W. Obianime. Evaluation of biochemical indices following administration of artemether, halofantrine and a combination of artemether and lumefantrine in guinea pigs. J App Pharm Sci. 2012; 2 (10): 054-059.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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