Research Article | Volume: 2 Issue: 10, October, 2012

Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae)

C. ZimudziL.F.GwenhureN.KunongaS. Kativu and J. Jere   

Open Access    DOI: 10.7324/JAPS.2012.21010

Abstract

Stem methanolic extract of Phyllanthus serpentinicola was screened for phytochemicals, and tested for cytotoxicity and anti-inflammatory activities. Tests indicated presence of alkaloids, tannins, terpenoids, reducing sugars and flavonoids. Saponins, anthraquinones, and cardiac glycosides were absent. Cytotoxic effects of the plant were assessed through Brine shrimp lethality (BSL) bioassay. An LC50 value of 1.3 µg/ml was found, thus indicating that the stem extract was strongly cytotoxic. Anti-inflammatory activity was assessed by the egg albumen induced hind paw oedema test on Swiss albino mice. The extract significantly (p


Keyword:     Phyllanthus serpentinicolaphytochemicalscytotoxicityBSL bioassayanti-inflammation


Citation:

C. Zimudzi, L.F.Gwenhure, N.Kunonga, S. Kativu and J. Jere. Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae). J App Pharm Sci. 2012; 2 (10): 050-053.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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