Research Article | Volume: 2 Issue: 7, July 2012

Cytotoxicity Activity and Phytochemical Screening of Cochlospermum tinctorium Perr Ex A. Rich Rhizome

Akpemi Audu Musa   

Open Access    DOI: 10.7324/JAPS.2012.2723

Abstract

Cytotoxicity activity experiment was carried out on the polar fractions of Cochlospermum tinctorium using the brine shrimp lethality bioassay method. The LC50 values of the extracts were determined by linear regression analysis method. It was observed that the 80% acetone extract LC50 value was 240 ± 3 µg/ ml, which was more potent compared to n-butanol extract with LC50 value of 437 ± 8 µg/ ml. Phytochemical test performed on both extracts showed that they contained cardiac glycosides, saponins and carbohydrates, while only the 80% acetone extract contains anthraquinones, flavonoids and tannins. These secondary metabolites present in both extracts, may likely accounts for their cytotoxic activity.


Keyword:     Brine shrimp lethality bioassaycytotoxicantitumorCochlospermum tinctoriumprobit analysisanticancer.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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