Review Article | Volume : 2 Issue : 6, June 2012

Coumarin: Chemical and Pharmacological Profile

P. K. Jain Himanshu Joshi   

Open Access    DOI: 10.7324/JAPS.2012.2643


Coumarins are classified as a member of the benzopyrone family. all of which consist of a benzene ring joined to a pyrone ring. The benzopyrones can be subdivided into the benzo-alfa-pyrones to which the coumarins belong and the benzo-gama-pyrones, of which the flavonoids are principal members. Umbelliferone, esculetin and scopoletin are the most widespread coumarins in nature. During the synthesis of these compounds ortho-hydroxylation should respectively take place on p-coumaric, caffeic and ferulic acid. The coumarins are of great interest due to their pharmacological properties. In particular, their physiological, bacteriostatic and anti-tumor activity makes these compounds attractive backbone derivatisation and screening as novel therapeutic agents.

Keyword:     Coumarin benzopyrone flavonoids anti-tumor activity bacteriostatic

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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