Review Article | Volume : 2 Issue : 6, June 2012
Open Access DOI: 10.7324/JAPS.2012.2641
Chronic administration of phenytoin has been associated to have a number of adverse effects. Falling serum folate levels is one such most often reported adverse drug sequelae of long term phenytoin usage. Folates administered at pharmacological doses, on the other hand, have been blamed for a decrease in the serum concentration of phenytoin, severe enough to precipitate seizures. This review substantiated with references from various studies focuses on the folic acid-phenytoin interaction and discusses the feasibility of using folate supplements to avoid such inadvertent drug sequelae in epileptic patients kept on chronic treatment with phenytoin.
Year
Month