Kerala’s anticancer flora: A comprehensive review

Mythili Srinivasan Ashwini Y. Chandane Amol A. Tagalpallewar Anil T. Pawar Manasi Nimbalkar Ranjit Nimbalkar Akshay M. Baheti   

Open Access   

Published:  May 22, 2024

DOI: 10.7324/JAPS.2024.180248

This ethnobotanical investigation explored native healing herbs for anticancer efficacy in Kerala’s Wayanad and Kozhikode districts. Insights were gathered from various stakeholders, including spice dealers, exporters, Ayurveda practitioners, tribal communities, and farmers, through discussions, interviews, and questionnaires from February 2021 to August 2022. Field expeditions to tribal settlements yielded crucial data on botanical nomenclature, common identifiers, vernacular names, traditional applications, and anecdotal applications. Following PRISMA guidelines, a systematic review incorporated a meta-analysis of 311 articles from Ovid Medline, Scopus, Web of Science, and PubMed. Results showed a significant overall effect (p-value 0.001), variable subgroup effectiveness (RR = 0.4118, p 0.009), and study-related impacts (p = 0.4837). Reliability was confirmed through sensitivity testing with negligible bias (p > 0.05). Despite notable unexplained heterogeneity (I² = 87.82%, H² = 8.21), the study emphasized the statistical significance of the selected medicinal plants. This investigation advances the ethnobotanical knowledge of Malabar’s anticancer herbs, underscoring the imperative for future research to exploit their therapeutic potential. It serves as pivotal groundwork for future developments in herbal medicine.

Keyword:     Anticancer ayurveda folklore uses medicinal plants phytoconstituents tribal communities meta-analysis


Srinivasan M, Chandane AY , Tagalpallewar AA, Pawar AT, Nimbalkar M, Nimbalkar R, Baheti AM. Kerala’s anticancer flora: A comprehensive review. J Appl Pharm Sci. 2024. Online First.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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