Carbendazim is a carbamate fungicide used in control of various fungal pathogens.Fenugreek (Trigonella foenum-graecum Linn.) is a leguminous plant cultivated in several Asian and African countries and its seeds are used as herbal medicine. In the present work the effect of aqueous extract of fenugreek seeds on carbendazim-induced testicular toxicity in albino rats was studied. Treating rats with carbendazim induced significant decrease in testis weights, diameters and germinal epithelial heights of the seminiferous tubules. Histological results revealed degeneration of seminiferous tubules and reduction of spermatogenic cells. Moreover, carbendazim caused elevation of testicular malondialdehyde (MDA), and reduced the activity of the antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Animals treated with carbendazim and fenugreek showed improvement in the histomorphological and histopathological changes observed in animals treated with carbendazim. In addition fenugreek treatment leads to a significant decrease in the level of MDA and increase in the activity of SOD and CAT. It is concluded that fenugreek extract can improve the testicular toxicity of carbendazim and this effect may be attributed to its antioxidant properties.
345 Absract views 6 PDF Downloads 351 Total views
Individual and combined biochemical and histological effect of Cypermethrin and Carbendazim in male albino ratsV. Muthuviveganandavel, P. Muthuraman, S. Muthu, K. Srikumar
Estimation of Phenolic content, Flavonoid content, Antioxidant and Alpha amylase Inhibitory Activity of Marketed Polyherbal Formulation
Ginger extract protects metalaxyl-induced histomorphological and histochemical alterations in testes of albino miceSaber A. Sakr and Somya Y. Shalaby
Suppressive effect of Ginkgo biloba extract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino rats
Anti-asthmatic and Anti-allergic effects of Thymoquinone on Airway-Induced Hypersensitivity in Experimental AnimalsAmira E. Abd El Aziz, Nesrine S. El Sayed, Laila G. Mahran