Research Article | Volume : 1 Issue : 9, November 2011

Individual and combined biochemical and histological effect of Cypermethrin and Carbendazim in male albino rats

V. Muthuviveganandavel P. Muthuraman S. Muthu K. Srikumar   

Open Access   

Abstract

Cypermethrin (CYP) and Carbendazim (CAR) are synthetic pesticides that have been in use for more than a decade. A study of a low-dose exposure of these pesticides in rat administered different doses of each of these compounds, individually and in combination, followed by investigation of the biochemical and histological status of the rat brain, will highlight early enzymatic and histological changes that generally accompanied a toxic response in the animal. Thus, even though CYP was used at 5, 10, 25 and 50mM, for durations of 12 and 24hr in the different groups of rats, results of the study indicate that simultaneous with changes in enzyme activity, histological sections of specific rat brain yielded observations suggestive of degenerating tissue morphology and architecture even at the low-dose levels.. Tissue specific changes in the activities of these marker enzymes were suggestive of the lack of tissue resistance to pyrethroids or carbamates.


Keyword:     Carbendazim Cypermethrin Enzymes Histology Rats.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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