Assessment of health-related quality of life and its contributing factors using the WHOQOL-BREF questionnaire in patients with chronic liver disease
Published:  Feb 08, 2023DOI: 10.7324/JAPS.2023.120282
Chronic liver disease (CLD) is a serious condition characterized by a progressive decline in liver functions, which leads to impaired quality of life (QOL). A prospective cross-sectional study was conducted with 165 patients to identify the health-related QOL in CLD, for 6 months. The QOL of CLD patients was assessed using the World Health Organization quality of life-BREF questionnaire and the severity of the disease was assessed using Child-Pugh Model for End-Stage Liver Disease (MELD) score. The incidence of CLD was found to be high in males (89.09%). While assessing, the overall QOL was identified as 50.96 ± 15.77. The highest score was observed in the social relationships domain (58.33 ± 19.34) followed by environment (54.74 ± 16.74), psychological (46.70 ± 19.81), and physical health (44.08 ± 18.64). The socio-demographic factors associated with QOL include body mass index, education, alcohol consumption, smoking, and tobacco. In the Child-Pugh MELD Score, the QOL was higher in class A (Good hepatic function) with a MELD score of 6–9 (1.9% mortality), the mean score being 60 ± 21 in contrast with the other classes. From the study, it is evident that CLD has a significant impact on the QOL. Patient-centric collaborative care, including physicians, nurses, pharmacists, and other health care providers are essential to improve the QOL.
Sagara MK, Gangadharan V, Sristhi R, Shaji B, Kellarai A, Joel JJ. Assessment of health-related quality of life and its contributing factors using the WHOQOL-BREF questionnaire in patients with chronic liver disease. J Appl Pharm Sci, 2023. https://doi.org/10.7324/JAPS.2023.120282
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