The efficacy of novel heterocyclic activators showed potential activity against mercuric chloride-induced acute renal failure in rats

Safaa H. Mohamed Dina S. El-kady Gamal A. Elmegeed Mahitab I. El-kassaby Abdel-Razik H. Farrag Mervat M Abdelhalim Naglaa A. Ali   

Open Access   

Published:  Nov 14, 2022

DOI: 10.7324/JAPS.2023.89473
Abstract

Mercury chloride (HgCl2) has a potent nephrotoxic effect. Synthesizing new heterocyclic steroids using some chemical strategies could be predictable to have promising efficiency against mercuric chloride-induced acute renal failure. Analytical and spectral data affirmed the structure of the unprecedented heterocyclic steroids. To assess their biological activities, rats were treated with tested compounds after HgCl(2) intraperitoneally injected, daily treatment for another month. In comparison with HgCl(2) group. Synthesized compounds significantly prevented increased serum levels of creatinine, urea, renal lipid peroxidation, and NO levels, decreasing serum GOT, GPT, ALP, TNF-α, and IL-1 β levels and lipid profile concentration, and showed a significant increase in HDL and CAT levels. They moreover, upregulated levels of Nephrin-2 and KIM-1 Genes Expression. Histopathological results supported our biochemical findings. Noteworthy, compounds 6 and 9 in particular, have more antioxidant and anti-inflammatory activities than compounds 4 and 5 and play a salutary role against HgCl2 toxicity. The biological characteristics of these new generations of heterocyclic steroid derivatives, which are demonstrated by their anti-inflammatory and antioxidant properties, could serve as a useful framework for the continued development of potent therapeutics.


Keyword:     Heterocyclic Steroids Mercuric chloride Kidney injury Inflammation


Citation:

Mohamed SH, El-kady DS, Elmegeed GA, El-kassaby MI, Farrag ARH, Abdelhalim MM, Ali NA. The efficacy of novel heterocyclic activators showed potential activity against mercuric chloride-induced acute renal failure in rats. J Appl Pharm Sci, 2022. https://doi.org/10.7324/JAPS.2023.89473

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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