A comprehensive review on the phytoconstituents and biological activities of Nyctanthes arbor-tristis L.

Ni Kadek Santi Maha Dewi Nanang Fakhrudin Subagus Wahyuono   

Open Access   

Published:  Jun 19, 2022

Abstract

Nyctanthes arbor-tristis (NAT) is one of the Indonesian herbal medicines which belongs to the genus Nyctanthes and the Oleaceae family. Traditionally, NAT is used to reduce fever and pain and treat hemorrhoids, irregular menstruation, cough, and asthma. This review article aimed to examine the phytoconstituents and pharmacological activities of NAT from different plant parts. The literature search was conducted through PubMed and Google Scholar databases. Our literature study showed that NAT has various secondary metabolites, such as steroids, terpenes, flavonoids, phenol, iridoid glycosides, and alkaloids. These compounds are distributed in the leaves, seeds, flowers, and stem bark. Different chemical structures of secondary metabolites are present in each plant part, and each demonstrates distinct pharmacological activities. The most common activities found in the literature are antimicrobial, analgesic, antiinflammatory, antidiabetic, antioxidant, hepatoprotective, antitussive, and antimalarial activities. Although this plant offers a promising source for drug discovery, the pharmacological and phytochemical data are still limited. Further studies are needed to explore the potency of NAT as natural products benefiting human health.


Keyword:     Herbal medicine nightflowering jasmine pharmacology secondary metabolite traditional use.


Citation:

Dewi NKSM, Fakhrudin N, Wahyuono S. A comprehensive review on the phytoconstituents and biological activities of Nyctanthes arbor-tristis L. J Appl Pharm Sci, 2022. Online First.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Agrawal J, Pal A. Nyctanthes arbor-tristis Linn-a critical ethnopharmacological review. J Ethnopharmacol, 2013; 146:645-58. https://doi.org/10.1016/j.jep.2013.01.024

Agrawal J, Shanker K, Chanda D, Pal A. Nyctanthes arbor-tristis positively affects immunopathology of malaria-infected mice prolonging its survival. Parasitol Res, 2013; 112:2601-9. https://doi.org/10.1007/s00436-013-3427-y

Ashwini P, Rekha PD. Lupeol from Nyctanthes arbor-tristis inhibits matrix metalloproteinase activity, angiogenesis and proliferation of glioma cells. Pharm Chem J, 2019; 53:160-4. https://doi.org/10.1007/s11094-019-01971-8

Bhadouria RS, Bhargava S, Pancholi SS. Isolation and characterization of two alkaloid from the ethanolic extract of Nyctanthes arbor-tristis L. Leaves, 2012; 2:342-4.

Chaudhary S, Gupta RK, Kumar A, Tarazi H. Hepatoprotective and antioxidant potential of Nyctanthes Arbor-tristis L. against antitubercular drugs induced hepatotoxicity. J Pharm Pharmcogn Res, 2018; 6:205-15.

Elfahmi, Woerdenbag HJ, Kayser O. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med, 2014; 4:51-73. https://doi.org/10.1016/j.hermed.2014.01.002

Gadgoli C, Shelke S. Crocetin from the tubular calyx of Nyctanthes arbor-tristis. Nat Prod Res, 2010; 24:1610-5. https://doi.org/10.1080/14786411003754363

Ghosh K, Ray S, Bera K, Ray B. Isolation and structural elements of a water-soluble free radical scavenger from Nyctanthes arbor-tristis leaves. Phytochemistry, 2015; 115:20-6. https://doi.org/10.1016/j.phytochem.2015.02.007

Godse CS, Tathed PS, Talwalkar SS, Vaidya RA, Amonkar AJ, Vaidya AB, Vaidya ADB. Antiparasitic and disease-modifying activity of Nyctanthes arbor-tristis Linn. in malaria: an exploratory clinical study. J Ayurveda Integr Med, 2016; 7:238-48. https://doi.org/10.1016/j.jaim.2016.08.003

Han N-R, Kim H-M, Jeong H-J. The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP. Exp Biol Med, 2014; 239:454-64. https://doi.org/10.1177/1535370213520111

Han SH, Hur MS, Kim MJ, Jung WH, Park M, Kim JH, Shin HJ, Choe YB, Ahn KJ, Lee YW. In vitro anti- Malassezia activity of Castanea crenata shell and oil-soluble Glycyrrhiza extracts. Ann Dermatol, 2017; 29:321. https://doi.org/10.5021/ad.2017.29.3.321

Haque M, Sultana N, Abedin S, Kabir S. Stigmasterol, rengyolone, 2-phenylethyl β-D-glucopyranoside and n-tetradecyl-βD-glucopyranoside from the flowers of Nyctanthes arbor-tristis Linn. Bangladesh J Sci Ind Res, 2019; 54:275-82. https://doi.org/10.3329/bjsir.v54i3.42680

Heendeniya SN, Keerthirathna LakshikaR, Manawadu CK, Dissanayake IH, Ali R, Mashhour A, Heendeniya SN, Keerthirathna LR, Manawadu CK, Dissanayake IH, Ali R, Mashhour A, Alzahrani H, Godakumbura P, Boudjelal M, Peiris DC. Therapeutic efficacy of Nyctanthes arbor-tristis flowers to inhibit proliferation of acute and chronic primary human leukemia cells, with adipocyte differentiation and in silico analysis of interactions between survivin protein and selected secondary metabolites. Biomolecules, 2020; 10:165. https://doi.org/10.3390/biom10020165

Hiremath V, Hiremath BS, Mohapatra S, Kumar Das A. Literary review of Parijata (Nyctanthus arbor-tristis Linn.) an herbal medicament with special reference to ayurveda and botanical literatures. Biomed Pharmacol J, 2016; 9:1019-25. https://doi.org/10.13005/bpj/1043

Kakoti BB, Pradhan P, Borah S, Mahato K, Kumar M. Analgesic and anti-inflammatory activities of the methanolic stem bark extract of Nyctanthes arbor-tristis Linn. BioMed Res Int, 2013; 2013:1-6. https://doi.org/10.1155/2013/826295

Karan BN, Maity TK, Pal BC, Singha T, Jana S. Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis : its potential biological activities in vitro assays. Nat Prod Res, 2019; 33:3287-92. https://doi.org/10.1080/14786419.2018.1470171

Khanapur M, Avadhanula RK, Setty OH. In Vitro antioxidant, antiproliferative, and phytochemical study in different extracts of Nyctanthes arbortristis flowers. BioMed Res Int, 2014; 2014:1-10. https://doi.org/10.1155/2014/291271

Kim K-S, Yang HJ, Lee J-Y, Na Y-C, Kwon S-Y, Kim Y-C, Lee J-H, Jang H-J. Effects of β-sitosterol derived from Artemisia capillaris on the activated human hepatic stellate cells and dimethylnitrosamineinduced mouse liver fibrosis. BMC Complement Altern Med, 2014; 14:363. https://doi.org/10.1186/1472-6882-14-363

Kumari P, Sahal D, Jain SK, Chauhan VS. Bioactivity Guided Fractionation of Leaves Extract of Nyctanthes arbor tristis (Harshringar) against P. falciparum. PLoS One, 2012; 7:e51714. https://doi.org/10.1371/journal.pone.0051714

Kumari S, Singh R, Gurav NP, Mehta N. Isolation and characterization of bioactive compounds from stem of nyctanthes arbortristis linn. and effect of different fractions on phytopathogens. Asian J Chem, 2017; 29:787-91. https://doi.org/10.14233/ajchem.2017.20306

Luo Y, Peng B, Wei W, Tian X, Wu Z. Antioxidant and antidiabetic activities of polysaccharides from guava leaves. Molecules, 2019; 24:1343. https://doi.org/10.3390/molecules24071343

Michael JS, Kalirajan A, Padmalatha C, Singh AJAR. In vitro antioxidant evaluation and total phenolics of methanolic leaf extracts of Nyctanthes arbor-tristis L. Chin J Nat Med, 2013; 11:484-7. https://doi.org/10.1016/S1875-5364(13)60088-6

Mishra AK, Upadhyay R, Chaurasia JK, Tiwari KN. Comparative antioxidant study in different flower extracts of Nyctanthes arbor-tristis (L.) (Oleaceae): an important medicinal plant. Braz J Bot, 2016a; 39:813-20. https://doi.org/10.1007/s40415-016-0283-x

Mishra RK, Mishra V, Pandey A, Tiwari AK, Pandey H, Sharma S, Pandey AC, Dikshit A. Exploration of anti-Malassezia potential of Nyctanthes arbor-tristis L. and their application to combat the infection caused by Mala s1 a novel allergen. BMC Complement Altern Med, 2016b; 16:114. https://doi.org/10.1186/s12906-016-1092-2

Moreira D de L, Teixeira SS, Monteiro MHD, De-Oliveira ACAX, Paumgartten FJR. Traditional use and safety of herbal medicines1. Rev Bras Farmacogn, 2014; 24:248-57. https://doi.org/10.1016/j.bjp.2014.03.006

Mousum SA, Ahmed S, Gawali B, Kwatra M, Ahmed A, Lahkar M. Nyctanthes arbor-tristis leaf extract ameliorates hyperlipidemia- and hyperglycemia-associated nephrotoxicity by improving anti-oxidant and antiinflammatory status in high-fat diet-streptozotocin-induced diabetic rats. Inflammopharmacology, 2018; 26:1415-28. https://doi.org/10.1007/s10787-018-0497-6

Nirmal SA, Pal SC, Mandal SC, Patil AN. Analgesic and antiinflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves. Inflammopharmacology, 2012; 20:219-24. https://doi.org/10.1007/s10787-011-0110-8

Nosá?ová G, Capek P, Matáková T, Nosá? S, Flešková D, Jure?ek ?. Antitussive activity of an extracellular Rhodella grisea proteoglycan on the mechanically induced cough reflex. Carbohydr Polym, 2012; 87:752-6. https://doi.org/10.1016/j.carbpol.2011.08.058

Park C, Jeong J-W, Han MH, Lee H, Kim G-Y, Jin S, Park J-H, Kwon HJ, Kim BW, Choi Y-H. The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis. Anim Cells Syst, 2021; 25:119-27. https://doi.org/10.1080/19768354.2021.1915380

Patel S, Gokhale M. Comparative study of antioxidant activity of ethanol and aqueous extracts of different parts of Nyctanthes Arbor-tristis Linn. Pharmacogn J, 2016; 8:113-6. https://doi.org/10.5530/pj.2016.2.3

Pawar N, Panchal S, Kawle D, Gadgoli C, Maru G. Evaluation of genotoxic and modulatory effects of Nyctanthes arbor-tristis calyx extract and the isolated crocin in Ames' assay. Nat Prod Res, 2019; 33:884-8. https://doi.org/10.1080/14786419.2017.1410807

Rangika BS, Dayananda PD, Peiris DC. Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice. BMC Complement Altern Med, 2015; 15:289. https://doi.org/10.1186/s12906-015-0807-0

Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. PLoS Pathog, 2012; 8:e1002701. https://doi.org/10.1371/journal.ppat.1002701

Sharma L, Dhiman M, Singh A, Sharma MM. Nyctanthes arbortristis L.: "an unexplored plant of enormous possibilities for economic revenue." Proc Natl Acad Sci India Sect B Biol Sci, 2021; 91:241-55. https://doi.org/10.1007/s40011-020-01213-y

Shen M, Hu Y, Yang Y, Wang L, Yang X, Wang B, Huang M. Betulinic acid induces ROS-dependent apoptosis and s-phase arrest by inhibiting the NF-κ B pathway in human multiple myeloma. Oxid Med Cell Longev, 2019; 2019:1-14. https://doi.org/10.1155/2019/5083158

Siraj A, Shams R, Hossain E, Salahuddin M, Tahsin F, Khalid AA, Paul SP. Assay of antidiabetic activity of Hemidesmus indicus by gut perfusion and six segment methods on Long Evans rats. Pharmacology, 2013; 3:81-7.

Sousa JLC, Gonçalves C, Ferreira RM, Cardoso SM, Freire CSR, Silvestre AJD, Silva AMS. Functionalization of betulinic acid with polyphenolic fragments for the development of new amphiphilic antioxidants. Antioxidants, 2021; 10:148. https://doi.org/10.3390/antiox10020148

Vajravijayan S, Nandhagopal N, Anantha Krishnan D, Gunasekaran K. Isolation and characterization of an iridoid, Arbortristoside-C from Nyctanthes arbor-tristis Linn., a potential drug candidate for diabetes targeting α-glucosidase. J Biomol Struct Dyn, 2020:1-11. https://doi.org/10.1080/07391102.2020.1813201

Wallander E, Albert VA. Phylogeny and classification of Oleaceae based on rps16 and trnL-F sequence data. Am J Bot, 2000; 87:1827-41. https://doi.org/10.2307/2656836

Wickramaratne MN, Punchihewa JC, Wickramaratne DBM. Invitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina. BMC Complement Altern Med, 2016; 16:466. https://doi.org/10.1186/s12906-016-1452-y

Article Metrics

0 Absract views 0 PDF Downloads 0 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required