Alstonia scholaris is a traditionally important medicinal plant. This evergreen tree is native to the Indian subcontinent and Southeast Asian countries. The plant is used in traditional, Ayurvedic, Unani, Homoeopathy and Sidhha/Tamil types of alternative medicinal systems against different ailments such as asthma, malaria, fever, dysentery, diarrhea, epilepsy, skin diseases, snakebite etc. Among the phytochemicals, alkaloids are mostly reported. This review compiles reports on phytochemical and pharmacological aspects of A. scholaris.