Research Article | Volume: 11, Supplement 1, March, 2021

Evaluation of the renoprotective effect of syringic acid against nephrotoxicity induced by cisplatin in rats

Hardevinder Pal Singh Thakur Gurjeet Singh Randhir Singh   

Open Access   

Published:  Feb 09, 2021

DOI: 10.7324/JAPS.2021.11s109
Abstract

The present study investigated the role of syringic acid (SA) in the renal protection mediated through the nitric oxide synthase (NOS) pathway in rodents treated with cisplatin (CP) with a single nephrotoxic dose of 5 mg/kg (i.p.) on the day the study commenced. The nephrotoxicity caused by a single dose of CP was assessed by measuring renal functional test (in serum and urine), oxidative stress parameters, and histopathological evaluation with hematoxylin and eosin stain in renal tissue on day 5, i.e., the last day of the study. The Administration of SA provides significant (p < 0.05) dose-mediated (50 and 100 mg/kg, p.o.) nephroprotection in CP-treated male Wistar rats. Pretreatment with NOS inhibitor, L-nitroarginine methyl ester (20 mg/kg, i.p.) in rats abolished the nephroprotective prospective of SA. SA-mediated activation of the NOS pathway has been hypothesized to contribute to renoprotection.


Keyword:     Cisplatin nephrotoxicity oxidative stress syringic acid nitric oxide synthase.


Citation:

Singh HP, Singh TG, Singh R. Evaluation of the renoprotective effect of syringic acid against nephrotoxicity induced by cisplatin in rats. J Appl Pharm Sci, 2021; 11 (Supp 1):080–085.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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