The present study investigated the role of syringic acid (SA) in the renal protection mediated through the nitric oxide synthase (NOS) pathway in rodents treated with cisplatin (CP) with a single nephrotoxic dose of 5 mg/kg (i.p.) on the day the study commenced. The nephrotoxicity caused by a single dose of CP was assessed by measuring renal functional test (in serum and urine), oxidative stress parameters, and histopathological evaluation with hematoxylin and eosin stain in renal tissue on day 5, i.e., the last day of the study. The Administration of SA provides significant (p < 0.05) dose-mediated (50 and 100 mg/kg, p.o.) nephroprotection in CP-treated male Wistar rats. Pretreatment with NOS inhibitor, L-nitroarginine methyl ester (20 mg/kg, i.p.) in rats abolished the nephroprotective prospective of SA. SA-mediated activation of the NOS pathway has been hypothesized to contribute to renoprotection.
Singh HP, Singh TG, Singh R. Evaluation of the renoprotective effect of syringic acid against nephrotoxicity induced by cisplatin in rats. J Appl Pharm Sci, 2021; 11 (Supp 1):080–085.
Abdel Moneim AE, Othman MS, Aref AM. Azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. Biomed Res Int, 2014; 2014:647131. https://doi.org/10.1155/2014/647131 | |
Alhoshani AR, Hafez MM, Husain S, Al-Sheikh AM, Alotaibi MR, Al Rejaie SS, Alshammari MA, Almutairi MM, Al-Shabanah OA. Protective effect of rutin supplementation against cisplatin-induced nephrotoxicity in rats. BMC Nephrol, 2017; 18(1):194. https://doi.org/10.1186/s12882-017-0601-y | |
Arab HH, Salama SA, Maghrabi IA. Camel milk ameliorates 5-Fluorouracil-induced renal injury in rats: targeting MAPKs, NF-κB and PI3K/Akt/eNOS pathways. Cell Physiol Biochem, 2018; 46(4):1628-42. https://doi.org/10.1159/000489210 | |
Cherla G, Jaimes EA. Role of L-arginine in the pathogenesis and treatment of renal disease. J Nutr, 2004; 134(10 Suppl):2801S-6S. https://doi.org/10.1093/jn/134.10.2801S | |
Cikman O, Soylemez O, Ozkan OF, Kiraz HA, Sayar I, Ademoglu S, Taysi S, Karaayvaz M. Antioxidant activity of syringic acid prevents oxidative stress in l-arginine-induced acute pancreatitis: an experimental study on rats. Int Surg, 2015; 100(5):891-6. https://doi.org/10.9738/INTSURG-D-14-00170.1 | |
Czambel RK, Kharlamov A, Jones SC. Variations of brain endothelial nitric oxide synthase concentration in rat and mouse cortex. Nitric Oxide, 2010; 22(1):51-7. https://doi.org/10.1016/j.niox.2009.11.006 | |
Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA, Khan F. Protective effect of nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. Biomed Pharmacother, 2017; 85:7-15. https://doi.org/10.1016/j.biopha.2016.11.110 | |
Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatininduced acute renal failure is associated with an increase in the cytokines interleukin(IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007; 322(1):8-15. https://doi.org/10.1124/jpet.107.119792 | |
Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 1980; 288(5789):373-6. https://doi.org/10.1038/288373a0 | |
Gharibi F, Soltani N, Maleki M, Talebi A, Nasiri M, Shirdavani S, Nematbakhsh M. The protective effect of l-arginine in cisplatin-induced nephrotoxicity in streptozotocin-induced diabetic rats. Adv Biomed Res, 2017; 6:100. https://doi.org/10.4103/2277-9175.212928 | |
Hopkins N, Cadogan E, Giles S, Bannigan J, McLoughlin P. Type 2 nitric oxide synthase and protein nitration in chronic lung infection. J Pathol, 2003; 199(1):122-9. https://doi.org/10.1002/path.1256 | |
Izzedine H, Perazella MA. Anticancer drug-induced acute kidney injury. Kidney Int Rep, 2017; 2(4):504-14. https://doi.org/10.1016/j.ekir.2017.02.008 | |
Jilanchi S, Talebi A, Nematbakhsh M. Cispaltin alters sodium excertion and renal clearance in rats: gender and drug dose related. Adv Biomed Res, 2018; 7:54. https://doi.org/10.4103/abr.abr_124_17 | |
Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia, 2012; 83(4):650-9. https://doi.org/10.1016/j.fitote.2012.01.010 | |
Kapil A, Singh JP, Kaur T, Singh B, Singh AP. Involvement of peroxisome proliferator-activated receptor gamma in vitamin-D mediated protection against acute kidney injury in rats. J Surg Res, 2013; 185(2): 774-83. https://doi.org/10.1016/j.jss.2013.07.017 | |
Kilic U, Kilic E, Tuzcu Z, Tuzcu M, Ozercan IH, Yilmaz O, Sahin F, Sahin K. Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway. Nutr Metab (Lond). 2013; 10(1):7. https://doi.org/10.1186/1743-7075-10-7 | |
Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimentalnephrotoxicity. J Agric Food Chem, 2007; 55(25):10150-5. https://doi.org/10.1021/jf0723965 | |
Kumar S, Prahalathan P, Raja B. Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. Naunyn Schmiedebergs Arch Pharmacol, 2012; 385(12):1175-84. https://doi.org/10.1007/s00210-012-0802-7 | |
Liu JQ, Cai GY, Wang SY, Song YH, Xia YY, Liang S, Wang W, Nie S, Feng Z, Chen X. The characteristics and risk factors for cisplatininduced acute kidney injury in the elderly. Ther Clin Risk Manag, 2018; 14:1279-85. https://doi.org/10.2147/TCRM.S165531 | |
Manohar S, Leung N. Cisplatin nephrotoxicity: a review of the literature. J Nephrol, 2018; 31(1):15-25. https://doi.org/10.1007/s40620-017-0392-z | |
Murohara T, Witzenbichler B, Spyridopoulos I, Asahara T, Ding B, Sullivan A, Losordo DW, Isner JM. Role of endothelial nitric oxide synthase in endothelial cell migration. Arterioscler Thromb Vasc Biol, 1999; 19(5):1156-61. ttps://doi.org/10.1161/01.ATV.19.5.1156 | |
Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, Ashrafi F. Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female. Nephrourol Mon, 2013; 5(3):818-21. https://doi.org/10.5812/numonthly.10128 | |
Noori S, Mahboob T. Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats. Indian J Clin Biochem, 2010; 25(1):86-91. https://doi.org/10.1007/s12291-010-0018-x | |
Ozturk H, Firat T, Tekce BK, Yilmaz F. Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction. Kaohsiung J Med Sci, 2017;33:236-45. https://doi.org/10.1016/j.kjms.2017.03.003 | |
Peres LA, da Cunha AD Jr. Acute nephrotoxicity of cisplatin: molecular mechanisms. J Bras Nefrol, 2013; 35(4):332-40. https://doi.org/10.5935/0101-2800.20130052 | |
Ramachandran V, Raja B. Protective effects of syringic acid against acetaminophen induced hepatic damage in albino rats. J Basic Clin Physiol Pharmacol, 2010; 21(4):369-85. https://doi.org/10.1515/JBCPP.2010.21.4.369 | |
Ramesh G, Reeves WB. TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest. 2002; 110(6):835-42. https://doi.org/10.1172/JCI200215606 | |
Sancaktutar AA, Bodakci MN, Hatipoglu NK, Soylemez H, Basarılı K, Turkcu G. The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in malerats. Urol Ann, 2014; 6(1):46-50. https://doi.org/10.4103/0974-7796.127029 | |
Sehajpal J, Kaur T, Bhatti R, Singh AP. Role of progesterone in melatonin-mediated protection against acute kidney injury. J Surg Res, 2014; 191(2):441-7. https://doi.org/10.1016/j.jss.2014.04.025 | |
Shahzad S, Mateen S, Naeem SS, Akhtar K, Rizvi W, Moin S. Syringic acid protects from isoproterenol induced cardiotoxicity in rats. Eur J Pharmacol, 2019; 849:135-45. https://doi.org/10.1016/j.ejphar.2019.01.056 | |
Singh S, Singh TG. Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach. Curr Neuropharmacol. 2020; 18(10):918-35. https://doi.org/10.2174/1570159X18666200207120949 | |
Singh AP, Singh N, Pathak D, Bedi PMS. Estradiol attenuates ischemia reperfusion-induced acute kidney injury through PPAR-γ stimulated eNOS activation in rats. Mol Cell Biochem. 2019; 453(1-2):1-9. https://doi.org/10.1007/s11010-018-3427-4 | |
Singh HP, Singh TG, Singh R. Sinapic acid attenuates cisplatininduced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats. J Pharm Bioallied Sci. 2020; 12(2):146-54. https://doi.org/10.4103/jpbs.JPBS_220_19 | |
Singh TG, Singh HP, Kaur S, Dhiman S. Protective effects of sesamol against cisplatin-induced nephrotoxicity in rats: a mechanistic approach. Obes Med, 2020; 19:100269. https://doi.org/10.1016/j.obmed.2020.100269 | |
Srinivasulu C, Ramgopal M, Ramanjaneyulu G, Anuradha CM, Suresh Kumar C. Syringic acid (SA) - A review of its occurrence, biosynthesis, pharmacological and industrial importance. Biomed Pharmacother, 2018; 108:547-57. https://doi.org/10.1016/j.biopha.2018.09.069 | |
Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. J Pharm Pharmacol, 2012; 64(6):872-81. https://doi.org/10.1111/j.2042-7158.2012.01470.x | |
Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem, 1994; 269(7):4705-8. https://doi.org/10.1016/S0021-9258(17)37600-7 | |
Zhang F, Siow YL, Karmin O. Hyperhomocysteinemia activates NF-κB and inducible nitric oxide synthase in the kidney. Kidney Int, 2004; 65(4):1327-38. https://doi.org/10.1111/j.1523-1755.2004.00510.x | |
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