Research Article | Volume: 3, Issue: 2, February, 2013

Protective Effect of Adiantum Capillus Against Chemically Induced Oxidative Stress by Cisplatin

Kanchan GaikwadSwati DhandeY M JoshiVilasrao Kadam   

Open Access   

Published:  Feb 27, 2013

DOI: 10.7324/JAPS.2013.30211
Abstract

Damage to cells caused by free radicals has been implicated in the disease progression of at least 50 diseases that is cancer, cardiovascular disease, renal dysfunction and other. So many factors contribute to oxidative stress. Hence, the present study was designed to investigate the potential nephroprotective activity of 250mg/kg and 500mg/kg. Ethanolic extract of Adiantum capillus-veneris dried fronds against Cisplatin induced oxidative stress caused in male Wistar rats. Acute nephrotoxicity was induced by i.p. injection of Cisplatin (7 mg/kg of body weight (b.w.)). Administration of ethanol extract at dose level of 500 and 250 mg/kg (b.w.) to Cisplatin-intoxicated rats (toxic control) for 14 days attenuated the biochemical and histological signs of nephrotoxicity of Cisplatin in dose-dependent fashion. Ethanol extract at 500 mg/kg decreased the serum level of creatinine and urea as compared to the toxic control group. The ethanol extract of Adiantum capillus-veneris at 500 mg/kg (b.w.) exhibited significant and comparable nephroprotective potential. The statistically (one-way-ANOVA followed by Dunnet’s test) processed results suggested the positive action of Adiantum capillus-veneris Cisplatin-induced nephropathy.


Keyword:     Cisplatin nephrotoxicity Adiantum capillus-veneris ethanolic extract


Citation:

Kanchan Gaikwad, Swati Dhande, Y M Joshi, Vilasrao Kadam., Protective Effect of Adiantum Capillus Against Chemically Induced Oxidative Stress by Cisplatin. J App Pharm Sci. 2013; 3 (02): 065-068.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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