Research Article | Volume: 8, Issue: 11, November, 2018

Evaluation of anticonvulsant effects of stem bark of Anogeissus latifolia (Roxb.) in mice

Vikas Chandra Sharma Atul Kaushik   

Open Access   

Published:  Nov 30, 2018

DOI: 10.7324/JAPS.2018.81110
Abstract

The stem bark of Anogeissus latifolia (Roxb.) (Family: Combretaceae) is used for the correction of various ailments in the traditional system of medicine. The present study aimed to investigate the anticonvulsant effect of the stem bark of A. latifolia (Roxb.). Anticonvulsant effect was assessed in maximal electroshock (MES) and pentylenetetrazol (PTZ)-induced convulsions in mice. Electric shock (50 mA for 0.2 seconds) was delivered with the help of corneal electrode to induce hind limb tonic extension, while pentylenetetrazol (80 mg/kg) was injected intraperitoneally to induce convulsion (clonic). Different concentrations of ethanolic extract of stem bark of A. latifolia (200, 400, and 600 mg/kg) were administered orally to mice. The ethanolic extract of stem bark of A. latifolia showed significant dose-dependent protection against seizures in both MES and PTZ-induced convulsion models. These findings suggested that ethanolic extract of stem bark of A. latifolia exhibited anticonvulsant effect against MES and PTZ-induced convulsions in a dose-dependent manner which may be attributed to the presence of ellagic acid and other tannins.


Keyword:     Dhava seizures phenytoin ellagic acid pentylenetetrazol.


Citation:

Sharma VC, Kaushik A. Evaluation of anticonvulsant effects of stem bark of Anogeissus latifolia (Roxb.) in mice. J App Pharm Sci, 2018; 8(11): 069–074.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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