Review Article | Volume : 2 Issue : 6, June 2012

Phenytoin-Folate Interactions: How Far is Safe Folate Supplementation in Phenytoin Treated Epileptic Patients?

Abhishek Singh Nayyar B. Nataraju G. T. Subhas   

Open Access    DOI: 10.7324/JAPS.2012.2641


Chronic administration of phenytoin has been associated to have a number of adverse effects. Falling serum folate levels is one such most often reported adverse drug sequelae of long term phenytoin usage. Folates administered at pharmacological doses, on the other hand, have been blamed for a decrease in the serum concentration of phenytoin, severe enough to precipitate seizures. This review substantiated with references from various studies focuses on the folic acid-phenytoin interaction and discusses the feasibility of using folate supplements to avoid such inadvertent drug sequelae in epileptic patients kept on chronic treatment with phenytoin.

Keyword:     Phenytoin anti-convulsant folate metabolism seizures.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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