Research Article | Volume: 8, Issue: 10, October, 2018

Evaluation of Multifunction Bioactivities of Extracted Chitosan and their UV/Ozone Derivatives

Tamer I. M. Ragab Gehan T. El-Bassyouni Wafaa A. Helmy Hanan A. A. Taie Ahmed Refaat Medhat A. Ibrahim Eman Abd El-Hmeed Mona A. Esawy   

Open Access   

Published:  Oct 31, 2018

DOI: 10.7324/JAPS.2018.81008

The objective of the present study was the extraction of chitosan from the seashell exoskeleton, then it was modified by the exposure to different time intervals of ultraviolet/ozone (UV/ozone). Also, the study focused on the differentiation between the properties of native chitosan and their UV/ozone forms. The molecular weight and degree of deacetylation of the extracted chitosan were determined. UV/ozone modified chitosan was analyzed using FTIR. The result proved that the irradiation of the prepared samples resulted in slight shifts in the absorbance bands position, also the occurrence of UV-induced photooxidation in the range of OH vibration. Molecular modeling at B3LYP/6-31g(d, p) and PM6 levels indicated that radiation was supposed to affect the H-bonding of the NH2 group through weak interaction with the six-respective hydrogen bonding in the three NH2 groups. UV/ozone chitosan acquired improvement in the antimicrobial activity by an increment of the exposure time against different pathogen with variable degrees. Antioxidant activity was determined using different methods and the results confirmed the role of UV/ozone in improving this property. The fibrinolytic activity reported that chitosan treated with UV/ozone for 3 and 4 h showed great activity. On the other hand, the anticoagulant activity was non-significant.

Keyword:     Chitosan UV/ozone Molecular modeling antimicrobial anticoagulant and fibrinolytic activity.


Ragab T, El-Bassyouni GT, Helmy W, Taie H, Refaat A, Ibrahim MA, Abd El-Hmeed E, Esawy MA. Evaluation of Multifunction Bioactivities of Extracted Chitosan and their UV/Ozone Derivatives. J App Pharm Sci, 2018; 8(10): 053-062.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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