Research Article | Volume: 8, Issue: 5, May, 2018

Synthesis, Antioxidant, and Anti-inflammatory Activity of Morpholine Mannich base of AMACs ((2E, 6E)-2-({4-hydroxy-3- [morpholin-4-yl-)methyl]phenyl}methylidene)-6-(phenylmethylidene) cyclohexan-1-one) and Its Analogs

Titah Nidya Putri Anton Bachtiar dan Hayun Hayun   

Open Access   

Published:  May 30, 2018

DOI: 10.7324/JAPS.2018.8503

A series of asymmetrical mono-carbonyl analogs of curcumin (AMACs) containing morpholine Mannich base ((2E, 6E)-2-({4-hydroxy-3-[morpholin-4-yl-)methyl]phenyl}methylidene)-6-(phenylmethylidene)cyclohexan- 1-one) was synthesized. The title compounds and the parent compounds were evaluated for antioxidant and anti-inflammatory activity using 2,2-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenger method and protein denaturation method, respectively. Among the tested compounds, only compound 3d showed potent antioxidant activity which was comparable to cyclovalone. All the AMACs exhibited lower anti-inflammatory activity than that of cyclovalone. However, compounds 4c and 4d exhibited a potent anti-inflammatory activity which was almost comparable to cyclovalone and the standard diclofenac sodium.

Keyword:     Asymmetrical mono-carbonyl analogs of curcumin AMACs Mannich base Morpholine Antioxidant Anti-inflammatory.


Putri TN, Bachtiar A, Hayun H. Synthesis, Antioxidant, and Anti-inflammatory Activity ofMorpholine Mannich base of AMACs ((2E, 6E)-2-({4-hydroxy-3-[morpholin-4-yl-)methyl] phenyl}methylidene)-6-(phenylmethylidene)cyclohexan-1-one) and Its Analogs. J App Pharm Sci, 2018; 8(05): 019-025.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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