Review Article | Volume: 8, Issue: 3, March, 2018

Roles of Polysaccharides in Transdermal Drug Delivery System and Future Prospects

Nor Maziah Saidin Nor Khaizan Anuar M.M.R. Meor Mohd Affandi   

Open Access   

Published:  Mar 30, 2018

DOI: 10.7324/JAPS.2018.8320
Abstract

This article reviews various polysaccharides used in transdermal drug delivery system. The system provides continuous controlled delivery of active ingredients through human skin and into the blood stream. Poor penetration of most drugs into the skin has led to numerous studies being conducted to increase the permeability of such drugs. Currently, the interest to utilize natural polysaccharides in transdermal formulations has increased as an alternative to the synthetic materials. Structure modification and polymer blending were carried out among polysaccharides and other materials in order to alter their functional properties. In some cases, the natural polymers provided better controlled release and drug permeation in comparison to the abilities of the synthetic materials. This review focuses on the physicochemical properties of polysaccharides and their effects on drug release profile, skin microstructure, and transdermal drug permeation. The limitations and future prospects of polysaccharides are also discussed.


Keyword:     Transdermal drug delivery system polysaccharide natural polymer penetration enhancer controlled release drug permeation.


Citation:

Saidin NM, Anuar NK, Meor Mohd Affandi M.M.R. Roles of Polysaccharides in Transdermal Drug Delivery System and Future Prospects. J App Pharm Sci, 2018; 8(03): 141-157.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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