Research Article | Volume: 7, Issue: 11, November, 2017

Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain

Tania Nasrin,  Mahia Khandaker,  Saleha Akter,  Mohammad Zafar Imam   
Tania Nasrin1, Mahia Khandaker2, Saleha Akter3, Mohammad Zafar Imam1

1Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka 1217, Bangladesh.

2Department of Biotechnology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Salna, Gazipur 1706, Bangladesh.

3Department of Pharmacy, Primeasia University, HBR Tower, Banani, Dhaka 1213, Bangladesh.

Open Access   

Published:  Nov 30, 2017

DOI: 10.7324/JAPS.2017.71121
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Abstract

Solanum sisymbriifolium Lamk. (Solanaceae) is a perennial prickly herb traditionally used in folk medicine to treat different ailments. This study evaluated the methanol extract of S. sisymbriifolium leaf (MSS) (100, 200, and 400 mg/kg; p.o.) for analgesic activity using heat- and chemical-induced pain models such as hot plate, tail immersion, formalin-induced licking and acetic acid-induced writhing. Interaction with the opioid receptor system was verified using naloxone to antagonize the effect of MSS, if any. MSS demonstrated significant and dose-dependent antinociceptive activity, though moderate, in both hot plate and tail immersion test (p < 0.05). Naloxone reversed the antinociceptive effect in both tests. MSS produced profound antinociceptive effect in formalin test and acetic acid-induced writhing at 400 mg/kg dose. These results imply that the antinociceptive effect of MSS is mainly due to its central effect and peripheral effects also contribute to some extent. These results provide preliminary evidence of antinociceptive activity of S. sisymbriifolium leaves and the potential of the plant in treating different painful conditions.


Keyword:     Solanum sisymbriifolium Solanaceae antinociceptive medicinal plant pain.

Citation:

Nasrin T, Khandaker M, Akter S, Imam MZ Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain. J App Pharm Sci, 2017; 7 (11): 142-146.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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