Research Article | Volume : 2 Issue : 4, April 2012

Antinociceptive activity of the methanol extracts of leaves of Eugenia fruticosa (Roxb.) and Glycosmis pentaphylla (Retz.) in Swiss albino mice

K. M. Shams-Ud-Doha Mehnaj Akter Zobaer Al Mahmud Apurba Sarker Apu Md. Amran Howlader   

Open Access    DOI: 10.7324/JAPS.2012.2405

Abstract

The present study was designed to evaluate analgesic potential of the methanolic extracts of the leaves of the both Glycosmis pentaphylla (Rutaceae) and Eugenia fruticosa (Myrtaceae). The analgesic activity was evaluated using the acetic acid (0.7% i.p.)-induced writhing inhibition method in swiss albino mice. The methanolic extract of leaves of Glycosmis pentaphylla, at the dose of 200 and 400 mg/kg body weight significantly (p<0.001) reduced the number of writhes with 31.97% and 44.21% of inhibition, respectively compared to control group. The methanolic extracts of leaves of Eugenia fruticosa significantly and dose dependently reduced the pain threshold (p<0.001) with 51.02 and 72.1% of writhing inhibition when compared to the control group at the dose of 200 and 400 mg/kg body weight, respectively which were comparable to that of the standard drug Diclofenac Na (65.31% inhibition of writhing, p<0.001). The results of the study demonstrated the potential antinociceptive activity of the methanolic extracts of the leaves of Glycosmis pentaphylla and Eugenia fruticosa which validated the traditional uses of the both plants in painful diseases and further investigations to elucidate the mechanism of action are required.


Keyword:     Glycosmis pentaphyllaEugenia fruticosa Methanolic extract Writhing Acetic acid Antinociceptive activity.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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