Research Article | Volume: 7, Issue: 11, November, 2017

Anticancer Activity of New Substituted Pyrimidines, Their Thioglycosides and Thiazolopyrimidine Derivatives

Mahmoud N. M. Yousif,  Wael A. El-Sayed,  Hebat-Allah S. Abbas ,  ,  Hanem M. Awad,  Nabil M. Yousif   
Mahmoud N. M. Yousif1, Wael A. El-Sayed1, Hebat-Allah S. Abbas1 , 2, Hanem M. Awad3, Nabil M. Yousif1

1Photochemistry Department, National Research Centre, El-Behouth St, Dokki, Cairo, Egypt.

2Chemistry Department, College of Science, King Khalid University, Abha, Saudi Arabia.

3Tanning Materials and Leather Technology Department, National Research Centre, El-Behouth St, Dokki, Cairo, Egypt.

Open Access   

Published:  Nov 30, 2017

DOI: 10.7324/JAPS.2017.71104
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Abstract

Novel functionalized pyrimidine, thioxopyrimidine, iminopyrimidine derivatives and their derived bicyclic thiazolopyrimidine compounds were synthesized. The substituted arylidine derivatives of the thiazolopyrimidine compounds were also prepared. Glycosylation of the thiopyrimidine derivative resulted in formation of the acetylated thioglycosides which were deacetylated to the free hydroxythioglycosides. The synthesized compounds were studied for their anticancer activity against hepatocellular carcinoma HepG-2, human prostate adenocarcinoma PC-3 and human colorectal carcinoma HCT-116 cell lines. Compounds 7c, 8a and 12a showed high activity against PC-3 cancer cells while compounds 11b and 12a revealed higher activity against HCT-116 cell line.


Keyword:     Pyrimidines Thiazolopyrimidines Thioglycosides Anticancer HCT-116 PC-3.

Citation:

Yousif MNM, El-Sayed WA, Abbas HS, Awad HM, Yousif NM. Anticancer Activity of New Substituted Pyrimidines, Their Thioglycosides and Thiazolopyrimidine Derivatives. J App Pharm Sci, 2017; 7 (11): 021-032.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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