Research Article | Volume: 7, Issue: 7, July, 2017

Exploring the Anticancer and Anti-Inflammatory Activities of Novel Diphenylthiazole-Amino Acid Conjugates

Eman G. Said Mohammed T. El-Saadi Ahmed H. Abdelazeem Samir M. El-Moghazy   

Open Access   

Published:  Jul 30, 2017

DOI: 10.7324/JAPS.2017.70731

Currently, there are sufficient evidences that there is a strong correlation between inflammation and cancer. In this regard, some NSAIDs such as celecoxib, were studied for the treatment and prevention of colon cancer. We herein have synthesized some novel diphenylthiazole-amino acids conjugates and evaluated their anticancer activity against three cancer cell lines; MCF-7, HT-29 and A549 using MTT assay. Furthermore, their anti-inflammatory activity was evaluated in vivo using carrageenan-induce paw edema assay. Compound 8a bearing methylglycine moiety exhibited the highest anticancer and anti-inflammatory activities with IC50 between 0.6 µM and 4.0 µM and edema inhibition% between 80 and 84, respectively.

Keyword:     Diphenylthiazole Amino acid Anticancer Anti-InflammatoryNSAIDs.


Said EG, El-Saadi MT, Abdelazeem AH, El-Moghazy SM. Exploring The Anticancer and Anti-Inflammatory Activities of Novel Diphenylthiazole-Amino Acid Conjugates. J App Pharm Sci, 2017; 7 (07): 212-217.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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