Research Article | Volume: 7, Issue: 6, June, 2017

Haematological and biochemical changes after exposure to Maerua crassifolia ethanol leaf extract in rats

Akuodor Godwin Christian,  Eban Linus Kechi,  Nku Clement Oshie,  Aja Daniel Ogbonna John,  Ezeunala Mercy Nwakaego,  Ajoku Gloria Ahunna,  Nwobodo Ndubuisi Nwobodo   
Akuodor Godwin Christian1, Eban Linus Kechi2, Nku Clement Oshie3, Aja Daniel Ogbonna John1, Ezeunala Mercy Nwakaego4, Ajoku Gloria Ahunna4, Nwobodo Ndubuisi Nwobodo1

1Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria.

2Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria.

3Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Nigeria.

4Department of Microbiology and Biotechnology, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria

Open Access   

Published:  Jun 30, 2017

DOI: 10.7324/JAPS.2017.70619
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Abstract

This study was carried out to determine the safety profile of Maerua crassifolia by conducting the acute and subacute toxicological assay of its ethanol leaf extract in rats. The animals were treated daily with the leaf extract at doses of 100, 200 and 400 mg/kg orally for 14 and 28 days. Rats used as control were given distilled water and all rats weighed every 7 days. After the test, haematological and biochemical parameters as well as their relative organs weight were determined. There were no significant changes in body weight of treated animals compared to control in both studies. In the acute toxicity test, the extract did not cause any signs of toxicity or produce mortality in rats. Subacute results showed that oral administration of the leaf extract did not significantly (p<0.05 affect their food consumption, haematological and biochemical parameters and relative organs weight. Findings in this study showed that Maerua crassifolia is endowed with the potential beneficial effects as immune booster and protecting the liver and kidney systems.


Keyword:     Maerua crassifolia Leaf extract HaematologicalBiochemical organ weight Rats.

Citation:

Christian AG, Kechi EL, Oshie NC, John ADO, Nwakaego EM, Ahunna AG, Nwobodo NN. Haematological and biochemical changes after exposure to Maerua crassifolia ethanol leaf extract in rats. J App Pharm Sci, 2017; 7 (06): 136-140.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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