Research Article | Volume: 3, Issue: 7, July, 2013

Protective Effect of Uvaria narum Bl. Leaves on Carbon Tetrachloride induced Hepatotoxicity in Rats

Jagir R. Patel Moses Samuel Rajan Shenoy Ashok Shabaraya A. R   

Open Access   

Published:  Jul 30, 2013

DOI: 10.7324/JAPS.2013.3731
Abstract

In the present study, Uvaria narum (Annonaceae) leaves were evaluated for its possible hepatoprotective potential. Elevation in hepatic biomarkers like SGPT, SGOT, ALP, bilirubin & other biochemical parameters like Cholesterol, triglycerides, urea & tissue LPO, where as decrease in total protein, albumin, glucose & tissue GSH, CAT, SOD was observed in CCl4 induced liver toxicity. Treatment with Silymarin, UNLE-200 and UNLE -400 resorted the altered hepatic biomarkers and biochemical parameters significantly in dose dependent manner. The biochemical observations were supplemented by histopathological examinations of liver sections. Relative organ weights were also reduced dose dependently in extract treated rats. Overall observations indicates that UNLE exerted remarkable hepatoprotective efficacy against CCl4 induced liver damage were comparable to reference standard Silymarin (100mg/kg) that is, may be due to its augmenting endogenous antioxidant mechanisms. These findings suggest the use of plant for treatment of liver diseases in oriental traditional medicine.


Keyword:     CCl4 silymarin UNLE-U.narum leaf extract Hepatopr


Citation:

Jagir R. Patel, Moses Samuel Rajan, Shenoy Ashok, Shabaraya A. R., Protective Effect of Uvaria narum Bl. Leaves on Carbon Tetrachloride induced Hepatotoxicity in Rats. J App Pharm Sci. 2013; 3 (07): 164-168.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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