Published:  Apr 30, 2017DOI: 10.7324/JAPS.2017.70414
Poly3-hydroxybutyric acid (PHB) is a promising eco-friendly substance favorable for medical use. PHB was produced from local isolate Bacillus thuringienesis in a conc. 4.1 g/L using 30 g/L Sugar-cane molasses (SCM) at pH 7.5 and incubation temperature 35oC. PHB biodegradation by soil microorganisms were completed after four weeks. Cell cytotoxicity testing is one of the critical factors affecting the biomedical application of polymers. 50% cell cytotoxic concentration (IC50) = 130 mg/mL while non-toxic concentration was 12.5 mg/mL studying of direct contact application between biopolymer and peripheral blood lymphocytes resulting monomers have no toxic effect on the cells.
El-Abd MAE, El-Sheikh HH, Desouky S, Shehab A. Identification, Biodegradation and bio-evaluation of biopolymer produced from Bacillus thuringenesis. J App Pharm Sci, 2017; 7 (04): 103-110.
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