Research Article | Volume: 7, Issue : 4, April, 2017

Identification, Biodegradation and bio-evaluation of biopolymer produced from Bacillus thuringenesis

Mostafa Abd El-Hameed El-Abd Hussein Hosny El-Sheikh Saeid Desouky Amr Shehab   

Open Access   

Published:  Apr 30, 2017

DOI: 10.7324/JAPS.2017.70414

Poly3-hydroxybutyric acid (PHB) is a promising eco-friendly substance favorable for medical use. PHB was produced from local isolate Bacillus thuringienesis in a conc. 4.1 g/L using 30 g/L Sugar-cane molasses (SCM) at pH 7.5 and incubation temperature 35oC. PHB biodegradation by soil microorganisms were completed after four weeks. Cell cytotoxicity testing is one of the critical factors affecting the biomedical application of polymers. 50% cell cytotoxic concentration (IC50) = 130 mg/mL while non-toxic concentration was 12.5 mg/mL studying of direct contact application between biopolymer and peripheral blood lymphocytes resulting monomers have no toxic effect on the cells.

Keyword:     PHB Bacillus thuringenesis biodegradation Cytotoxicity.


El-Abd MAE, El-Sheikh HH, Desouky S, Shehab A. Identification, Biodegradation and bio-evaluation of biopolymer produced from Bacillus thuringenesis. J App Pharm Sci, 2017; 7 (04): 103-110.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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