Research Article | Volume: 7, Issue : 4, April, 2017

Nutritional effects, toxicity and haematology studies of the ethanolic root bark extract of Hymenocardia acida Tul (Euphorbiaceae)

Paul N. Olotu,  Ijeoma A. Olotu,  Mighi B. Kambasha,  Abubakar Ahmed,  Ukpe Ajima,  Temitayo L. Ohemu,  Victoria A. Okwori,  Dalen G. Dafam,  Francis M. Agwom,  Jane David,  Emmanuel U. Onche   
Paul N. Olotu1, Ijeoma A. Olotu2, Mighi B. Kambasha1, Abubakar Ahmed3, Ukpe Ajima4, Temitayo L. Ohemu1, Victoria A. Okwori1, Dalen G. Dafam1, Francis M. Agwom4, Jane David5, Emmanuel U. Onche6

1Department of Pharmacognosy & Traditional Medicine, Faculty of Pharmaceutical Sciences, University of Jos, PMB 2084, Jos, Nigeria.

2Department of Biochemistry, Faculty of Medical Sciences, University of Jos, PMB 2084, Jos, Nigeria.

3Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, Ahmadu Bello University Zaria, Nigeria.

4Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Jos, PMB 2084, Jos, Nigeria.

5Department of Medical Biotechnology, National Biotechnology Development Agency, Abuja, Nigeria.

6School of Chemistry, University of Manchester, United Kingdom.

Open Access   

Published:  Apr 30, 2017

DOI: 10.7324/JAPS.2017.70415
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Abstract

The plant Hymenocardia acida has been used traditionally for decades in Northern Nigeria for the management of different types of pain such as chest-pain, rheumatic pain, tooth ache etc. It is also claimed to be beneficial in the ethno-medicinal management of sickle cell anaemia. The present study evaluates the nutritional properties, toxicity and haematological profile of the ethanolic root bark extract of the plant. Investigation of the acute toxicity of the extract in mice showed it to be safe and well tolerated on oral administration even up to doses of 6,000 mg/kg body weight. Histopathological studies on chronic administration of the extract in mice showed no observable organ damage at low dose but at higher doses, a focal area of hepatic necrosis was observed. The globule cells of the intestine were covered with progressive mucin and lymphocyte proliferations were observed within the spleen. Analysis of the blood parameters showed very significant increase in red blood cell count. The results obtained provide a rational basis for some of the uses of the plant in traditional medicine practice.


Keyword:     Nutrition Acute toxicity chronic toxicity Haematology Hymenocardia acida.

Citation:

Olotu PN, Olotu IA, Kambasha MB, Ahmed A, Ajima U, Ohemu TL, Okwori VA, Dafam DG, Agwom FM, David J, Onche EU. Nutritional effects, toxicity and haematology studies of the ethanolic root bark extract of Hymenocardia acida, Tul (Euphorbiaceae). J App Pharm Sci, 2017; 7 (04): 111-114.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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