Research Article | Volume: 5, Supplement: 2, September, 2015

Toxicological Investigation of Ethanolic Extract of Epipremnum aureum in Rodents

Sreemoy Kanti Das Pinaki Sengupta Mohd. Shahimi Mustapha Arindam das Md. Moklesur Rahman Sarker Muhammad Kifayatullah   

Open Access   

Published:  Sep 04, 2015

DOI: 10.7324/JAPS.2015.58.S9
Abstract

The present study was aimed to explore the acute and sub chronic toxicity studies with orally administered ethanolic leave extract of Epipremnum aureum. For the acute toxicity study, the animals were divided into four groups and each group receives a dose of (50, 500, 2000) mg/kg except control group which receives only 1% CMC. They were observed for 14days for signs of toxicity. In case of sub chronic toxicity, the Sprague dawley rats were fed with ethanol extract (100, 600, and 1000) mg/kg per day for 28 days. The parameters measured include organ weight, biochemical test, haematological test and histopathological observations. Acute oral administration of Epipremnum aureum did not show any mortality, CNS and ANS toxicities. Similarly in subchronic toxicity studies, Epipremnum aureum did not show any visible signs of toxicity. There were also no significant differences between the control and extract treated groups in terms of their organ weight, haematological and biochemical parameters. Histopathological examination did not reveal any remarkable and treatment related changes. A no-observed adverse-effect level for extract is 2000 mg/kg for rats under the conditions of this study. Hence, the extracts could be considered safe at the doses administered since they did not provoke toxic effect on the key organs examined and also did not alter any biochemical and haematological parameters.


Keyword:     Acute toxicity Blood analysis Sub chronic toxicity Epipremnum aureum.


Citation:

Sreemoy Kanti Das, Pinaki Sengupta, Mohd. Shahimi Mustapha, Arindam das, Md. Moklesur Rahman Sarker, Muhammad Kifayatullah. Toxicological Investigation of Ethanolic Extract of Epipremnum aureum In Rodents. J App Pharm Sci, 2015; 5 (Suppl 2): 057-061.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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