Research Article | Volume: 7, Issue: 3, March, 2017

In Vitro Cytotoxic Activity of Laurencia papillosa, Marine Red Algae from the Lebanese Coast

Mona Y. Tannoury Antoine M. Saab Josiane M. Elia Nafez N. Harb Hassane Y. Makhlouf Mona Diab-Assaf   

Open Access   

Published:  Mar 30, 2017

DOI: 10.7324/JAPS.2017.70328
Abstract

Marine algae are an excellent source of bioactive compounds with a variety of biological activities. This paper presents a study on the cytotoxic activity of Laurencia papillosa (Rhodomelaceae), marine red algae collected at the Lebanese coast against the human cancer cell line Jurkat (acute lymphoblastic leukemia) through the trypan blue exclusion assay. The results show that the percentage of cell viability was reduced by increasing the concentration of both algal extracts: ethanol/ water extract, and ethanol/ chloroform extract. The ethanol/ chloroform extract exhibits the highest levels of cytotoxicity with IC50 value of 57.77 µg/ mL against Jurkat cancer cell line especially after 72 hours of treatment compared with the ethanol/water extract with IC50 value of 121.642 µg/ mL. Further research should be explored in order to study the bioactive compounds of Laurencia papillosa that could be potentially useful therapeutic agents for patients with acute lymphoblastic leukemia.


Keyword:     Red algae Laurencia papillosa cytotoxic activity Jurkat trypan blue exclusion test.


Citation:

Saab A, Tannoury M, Harb JEN, Makhlouf H, Assaf MD. In Vitro Cytotoxic Activity of Laurencia papillosa, Marine Red Algae from the Lebanese Coast. J App Pharm Sci, 2017; 7 (03): 175-179.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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