Research Article | Volume: 6, Issue: 11, November, 2016

Synthesis of a series of pyrazoline derivatives carrying tosyl substitution and evaluation of their antimicrobial properties

Shubhalaxmia,  B. S. Manjunathaa,  K. Anandab,  K. Subrahmanya Bhata   
Shubhalaxmia, B. S. Manjunathaa, K. Anandab, K. Subrahmanya Bhata

aDepartment of Chemistry, Manipal Institute of Technology, Manipal University, Manipal-576 104, India.

bBiological Sciences Division, Poornaprajna Institute of Scientific Research, Devanahalli, Bangalore-562 164, India.

Open Access   

Published:  Nov 29, 2016

DOI: 10.7324/JAPS.2016.601133
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Abstract

A series of pyrazoline derivatives with tosyloxy substitution were synthesized and characterized. They were evaluated for antimicrobial potential against Mycobacterium smegmatis, gram positive Staphylococcus aureus, gram negative Escherichia coli, and a fungi Candida albicans. The initial screening using zones of inhibition at 50µL concentrations revealed that they are moderately active against the tested strains, and therefore further studies have not been carried out.


Keyword:     2-Pyrazolines Chalcones Antimicrobial properties.

Citation:

Shubhalaxmi, Manjunatha BS, Ananda K, Bhat KS. Synthesis of a series of pyrazoline derivatives carrying tosyl substitution and evaluation of their antimicrobial properties. J App Pharm Sci, 2016; 6 (11): 214-217.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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