Research Article | Volume: 6, Issue: 11, November, 2016

In-vivo Inhibition of Glutathione S-Transferase P1 by Bovine Lactoferricin in Swiss Albino Tumor Bearing Mice

Amir Riyaz KhanPankaj Taneja   

Open Access   

Published:  Nov 29, 2016

DOI: 10.7324/JAPS.2016.601132
Abstract

Many cancers overexpress GSTP1 which contributes to multidrug resistance via conjugation of antineoplastic drugs. The aim of this paper is to investigate the in-vivo interaction of GSTP1 and Lfcin B in Swiss albino female mice induced with skin cancer using 7, 12 dimethylbenz (a) anthracene. Group B and C received topical application of DMBA, whereas group C was subcutaneously injected with 200μl (20μg/μl) Lfcin B while keeping group A as a control. The activity of GSTP1 in all the groups was then estimated spectrophotometrically at 340nm by taking the increase in absorbance of GS-DNB conjugate. Administration of 200μl (20μg/μl) Lfcin B three times per week was found to significantly (p


Keyword:     In vivo GSTP1 Lfcin B Tumor Skin Cancer Enzyme Inhibition.


Citation:

Khan AR, Taneja P. In-vivo Inhibition of Glutathione S-Transferase P1 By Bovine Lactoferricin in Swiss Albino Tumor Bearing Mice. J App Pharm Sci, 2016; 6 (11): 210-213.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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