Research Article | Volume: 5, Issue: 11, November, 2015

Synthesis and in vitro Anti Microbial Evaluation Including Anti-Malarial Activity of Pyrazole Based Novel Cinnoline Derivatives

S. Hurmath Unnissa Nilofer Nisha Gayam Krishna Reddy   

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501121
Abstract

A Series of 4-methyl-3-[5-(substituted phenyl)-4, 5-dihydro-1H-Pyrazol-3-yl] Cinnoline-6-Sulfonamide were synthesized from 4-methyl-3-acetylcinnoline-6-Sulfonamido chalcones and hydrazines. The structure of the synthesized compounds were characterized by UV, IR, NMR & Mass spectral data, and evaluated for their in vitro anti-malarial and anti-bacterial activity to get new congeners as analogs of Pyrazole based Cinnoline compounds as a potent anti-Malarial and anti-microbial agents. All analogues exhibited in vitro anti-malarial activity against Plasmodium falciparum and all the analogues showed good anti-bacterial activity against various pathogenic microbes.


Keyword:     Cinnoline pyrazole Plasmodium falciparum anti-bacterial chalcones.


Citation:

Unnissa SH, Nisha N, Reddy GK. Synthesis and in Vitro Anti Microbial Evaluation Including Anti-Malarial Activity of Pyrazole Based Novel Cinnoline Derivatives. J App Pharm Sci, 2015; 5 (11): 121-126.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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