Research Article | Volume: 6, Issue: 11, November, 2016

Lipid-Based Delivery System for Topical Phenytoin

Siang Yin Lee Yeong Yaw Pung Boon Kuang Khor Wei En Kong Cai Ting Tan Siew Yong Teo   

Open Access   

Published:  Nov 29, 2016

DOI: 10.7324/JAPS.2016.601103

The wound healing effect of topical phenytoin has been reported but its effective delivery system is still under-researched. The present work aimed to formulate topical lipid-based gels for effective delivery of phenytoin. Three lipid-based emulsions with different droplet sizes were prepared using coconut kernel oil (CKO) and soybean oil (SBO) blends as an oil phase. Stable lipid-based emulsion with 100% emulsion stability index (ESI) over seven heating/cooling cycles could only be formed when the oil droplet satisfied the nano size criterion, as demonstrated by nano-emulsion. The stability of macro-emulsion and cream could be enhanced by the addition of Aristoflex ammonium acryloyldimethyl-taurate/VP (AVC) copolymer as the gelling agent. These gels, designated as nano-emulgel, macro-emulgel and cream-gel, were subsequently loaded with phenytoin. All gels exhibited non-Newtonian and shear-thinning flow behavior, with high yield stress ranged 18.8 – 51.5 Pa. The in vitro drug release profiles of all formulations followed the first-order kinetic model, with R2 > 0.95. It was found that lipid nano-emulgel demonstrated the highest release rate of phenytoin, with 93.12% drug released in 12 hours, followed by cream-gel with 56.42% and macro-emulgel with 51.51%. CKO/SBO nano-emulgel was identified as the most suitable lipid topical gel formulation for effective delivery of phenytoin.

Keyword:     Cream-gel lipid macro-emulgel nano-emulgel phenytoin topical.


Lee SY, Pung YY, Khor BK, Kong WE, Tan CT, Teo SY. LipidBased Delivery System for Topical Phenytoin. J App Pharm Sci, 2016; 6 (11): 014-020.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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