Research Article | Volume: 6, Issue: 10, October, 2016

Protective Effects of Solanum erianthum D. Don Leaf Extract on Lead-Induced Toxicity in Adult Wistar Rats

Olusegun Babalola John Agbi Adeleke Badiora Oladayo Areola   

Open Access   

Published:  Oct 29, 2016

DOI: 10.7324/JAPS.2016.601016
Abstract

The possible protective effects of the ethyl acetate fraction of Solanum erianthum ethanol leaf extract on lead-induced toxicity in adult Wistar rats were investigated. Phytochemical constituents, antioxidant and membrane stabilizing activities of the ethanol extract and its fractions were determined using standard procedures. Acute and sub-chronic oral toxicity studies were carried out. The rats were treated orally with lead (10 mg/kg b. wt) and extract (100 mg/kg b. wt). The blood samples, liver, and kidney were collected for the estimation of biochemical and organ parameters, and histomorphological studies. The ethyl acetate fraction had the highest antioxidant activities and high membrane stabilizing potentials when compared to the crude extract and other fractions. Significant elevations were observed in plasma albumin, creatinine and urea levels in group treated with lead only. The activities of plasma ALT and AST were significantly increased in group treated with lead alone. Treatment with ethyl acetate fraction significantly decreased (p < 0.05) the elevated ALT, AST, urea and creatinine levels. The histology evidence showed progressive degeneration of the liver and kidney tissues in lead treated groups while the administration of S. erianthum showed appreciable degrees of protection to both the liver and kidney. The study concluded that ethyl acetate fraction of S. erianthum has protective effects against lead-induced toxicity in adult Wistar rats.


Keyword:     Lead-induced toxicity Solanum erianthum ethyl acetate fraction acute toxicity sub-chronic toxicity histology.


Citation:

Agbi AJ, Badiora AS, Areola JO, Babalola OO. Protective Effects of Solanum Erianthum D. Don Leaf Extract on Lead-Induced Toxicity in Adult Wistar Rats. J App Pharm Sci, 2016; 6 (10): 113- 123.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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