Research Article | Volume: 6, Issue: 7, July, 2016

Phytochemical analysis, Anti inflammatory activity, in vitro antidiabetic activity and GC-MS profile of Erythrina variegata L. bark

Nagaraj SanthiyaSuriyamoorthy PriyangaSubrhamanian HemmalakshmiKanakasabapathi Devaki   

Open Access   

Published:  Jul 28, 2016

DOI: 10.7324/JAPS.2016.60722
Abstract

Many beneficial medicinal products are used to treat various serious diseases and disorders like diabetes, cancer and cardiovascular diseases without side effects. Hence our study focused to investigate the phytochemical analysis, quantification of bioactive compounds (alkaloid, phenols, flavonoids), in vitro free radical scavenging activity, anti-inflammatory activity (Membrane stabilization assay), in vitro anti-diabetic activity by enzyme inhibition activity, glucose uptake assay in isolated rat hemi-diaphragm and in yeast cells and also record GC-MS profile of Erythrina variegata L. bark (methanolic extract) which has boundless medicinal properties. The results of this study showed the evidence that the extracts when tested for their phytochemicals and free radical scavenging activity were found to have considerable antioxidant potential. This plant also exhibit better in vitro enzyme inhibitory activity, inhibition of non- enzymatic glycosylation of hemoglobin, in vitro anti-diabetic activity proved by glucose uptake assays and anti-inflammatory activity. GC-MS analysis of methanolic extract of Erythrina variegata L. bark revealed the presence of 58 compounds which are responsible for pharmacological activities. The results of this study indicate that the methanolic extract of Erythrina variegata L. bark has significant pharmacological properties.


Keyword:     E. variegataPhytoconstituentsDPPHGlycosylation of hemoglobinGC-MS.


Citation:

Santhiya N, Priyanga S, Hemmalakshmi S, Devaki K. Phytochemical analysis, Anti inflammatory activity, In vitro antidiabetic activity and GC-MS profile of Erythrina variegata L. bark. J App Pharm Sci, 2016; 6 (07): 147-155.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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