Research Article | Volume: 6, Issue: 7, July, 2016

A study on the effects of the alcoholic extract of the aerial parts of Echinophora platyloba on the activity of pituitary-gonadal axis in hypercholesterolemic rats

Sokhandani Mansour Zarei Ali Changizi-Ashtiyani Saeed   

Open Access   

Published:  Jul 28, 2016

DOI: 10.7324/JAPS.2016.60717
Abstract

The present experimental study was carried out to examine the effects of the alcoholic extract of the aerial parts of Echinophora platyloba on prolactin (PRL) levels and the activity of pituitary-gonadal axis in animal model. Forthy male wistar rats were divided into five groups: control group with normal diet, hypercholesterolemic group with fat diet, and three experimental groups which received Echinophora platyloba alcoholic extract as gavage at the minimum dose of 100, the average dose of 200, and the maximum dose of 400 mg/kgbw over a period of 21 days. At the end of the period, to assess the levels of PRL, cholesterol, testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH), blood samples were taken and data were analyzed. The levels of testosterone and cholesterol in hypercholesterolemic group compared to the control, showed a significant decrease and increase, respectively (P≤0.05). Echinophora platyloba extract caused significant increases in testosterone, PRL and a significant decrease in cholesterol levels (P≤0.05), however, it had no significant effect on the levels of LH and FSH. The results of this study showed that the consumption of alcoholic extract of Echinophora platyloba is effective in reducing serum cholesterol, increasing testosterone production and enhancing sexual performance.


Keyword:     Echinophora platyloba Prolactin Pituitary gland Testosterone Rats.


Citation:

Sokhandani Mansour, Zarei Ali, Changizi-Ashtiyani Saeed., A study on the effects of the alcoholic extract of the aerial parts of Echinophora platyloba on the activity of pituitary-gonadal axis in hypercholesterolemic rats. J App Pharm Sci, 2016; 6 (07): 115-119.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
333 Views 16 Downloads 349 Total

Year

Month

Related Search

By author names