Research Article | Volume: 6, Issue: 7, July, 2016

Impact analysis of inclusion complexation on micromeritic properties and dissolution behavior of carvedilol

Khandaker Sagir Ahmed Md. Abdullah Al Masum Sabiha Sultana Mohiuddin Ahmed Bhuiyan Md. Selim Reza   

Open Access   

Published:  Jul 28, 2016

DOI: 10.7324/JAPS.2016.60716
Abstract

The study aimed at investigating an inclusion complexation technique to improve solubility and dissolution characteristics of carvedilol by successful complexation with β-cyclodextrin. Inclusion complexes (ICs) of drug and β-cyclodextrin were prepared by kneading method in four different ratios. Physical mixtures were also prepared in identical ratios to compare the efficacy of prepared ICs. The preparations were subjected to rheological studies, drug loading, in vitro release study, FT-IR spectroscopy, thermal events analysis by DSC, X-ray diffraction, scanning electron microscopy (SEM) and accelerated stability study. IC granules were free flowing and compressible. FT-IR study denoted to absence of any chemical interactions between drug and carrier. DSC and X-ray diffraction suggested the presence of crystalline drug in the complexes. Dissolution of ICs revealed significant enhancement of release rate and extent compared to untreated drug. MDT, %DE and T25%, T50% and T80% indicated marked improvement in release rate from complexes. Kinetic modeling suggested that fickian diffusion was the predominant mechanism of drug release from solid complexes. Stability samples showed no significant alterations in DSC and FT-IR studies that referred to the stability of ICs. ICs were compatible, effective and stable over time. Further studies can be planned to investigate their therapeutic efficacy.


Keyword:     Complexation carvedilol cyclodextrin crystallinity and kinetic modeling.


Citation:

Ahmed KS, Al-Masum MA, Sultana S, Bhuiyan MA, Reza MS. Impact analysis of inclusion complexation on micromeritic properties and dissolution behavior of carvedilol. J App Pharm Sci, 2016; 6 (07): 106-114.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
366 Views 16 Downloads 382 Total

Year

Month

Related Search

By author names