Research Article | Volume: 6, Issue: 7, July, 2016

Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats

Babatunji Emmanuel Oyinloye Basiru Olaitan Ajiboye Oluwafemi Adeleke Ojo Habiba M. Musa Sunday Amos Onikanni Abiodun Ayodele Ojo   

Open Access   

Published:  Jul 28, 2016

DOI: 10.7324/JAPS.2016.60714
Abstract

The present study was undertaken to explore the ameliorative potential of aqueous extract of Aframomum melegueta (AM) on cadmium-induced hepatic damage in rats. Toxicity was induced by daily administration of 200 mg/L cadmium: Cd (Cd as CdCl2) in the animals’ main drinking water for 21 days. Lipid peroxidation (LPO), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were determined in the liver while total protein, albumin, direct bilirubin and total bilirubin concentration as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were monitored in the serum and histological examination was carried out. Exposure to cadmium resulted in various alterations in all the evaluated parameters. Treatment with AM (200 or 400 mg/kg bw) extract showed a significant (P <0.05) reversal effect that mitigated the deleterious effect of cadmium. Results of the histological examination also support the above findings. The results suggest that aqueous extracts of A. melegueta when administered orally, could ameliorate cadmium-associated oxidative stress in male Wistar rats in a dose dependant manner via its free radical-scavenging mechanism which could be linked to the synergetic effects between the bioactive constituents present in the extract.


Keyword:     Aframomum meleguetaAntioxidant aqueous extract cadmium toxicity hepatoprotective.


Citation:

Oyinloye BE, Ajiboye BO, Ojo OA, Musa HM, Onikanni SA, Ojo AA. Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats. J App Pharm Sci, 2016; 6 (07): 094-099.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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