Research Article | Volume: 3, Issue: 9, September, 2013
Research Article | Volume: 3, Issue: 9, September, 2013
This present study was performed to evaluate the hepatoprotective effect of Aframomum melegueta seeds, used as spicy in the traditional conditions. The hepatoprotective activity of the seeds of A. melegueta at 100 and 150 mgEq.pp/kg, administered orally, was assessed using carbon tetrachloride-induced (CCl4) liver damage (1 ml/kg bw 1:1 CCl4 and corn oil). The results obtained from this study show that A. melegueta produced a significant decrease in serum transaminases and alkaline phosphatase. At the dose of 150 mg Eq.pp/kg, A. melegueta induced a significant increase in serum total proteins. Liver and serum antioxidant potentials were also significantly increased. Those results indicate that A. melegueta seeds protect the liver against toxicity induced in this study.
Idoh Kokou, Karou S. Damintoti, Agbonon Amegnona, Adjrah Yao, Gbeassor Messanvi., Effetct of Aframomum melegueta on carbon tetrachloride induced liver injury. J App Pharm Sci, 2013; 3 (09): 098-102.
Year
Month
Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats
Comparative effect of chronic administration of chloroquine phosphate and methanol extract of Landolphia owariensis on the activities of rat Enzymes
Ilesanmi F F, Balogun E A, Ilesanmi O SFunctionalization and evaluation of PEGylated Carbon Nanotubes as novel Drug delivery for methotrexate
Chetana D. Modi, Suketu J. Patel, Alpesh B. Desai, R. S. R. Murthy