Research Article | Volume: 6, Issue: 1, January, 2016

Development of pioglitazone hydrochloride lipospheres by melt dispersion technique: Optimization and evaluation

Umesh M Bhosale Upendra C Galgatte Pravin D Chaudhari   

Open Access   

Published:  Jan 26, 2016

DOI: 10.7324/JAPS.2016.600118
Abstract

The objective of the present study was to develop and evaluate pioglitazone hydrochloride loaded lipospheres for treatment of diabetes. Pioglitazone hydrochloride lipospheres were formulated by using melt dispersion (homogenization) technique using compritol®888 ATO as lipid matrix and Phospholipon 90G (P 90G), PVA, Poloxamer 188 as surfactants. Formulation was optimized by using 32 full factorial design where entrapment efficiency and particle size were dependent variables and lipid and surfactant concentration were independent variables. Optimized formulation of pioglitazone hydrochloride (PLS 5) shows 79.69± 1.35% entrapment efficiency, 94.63± 2.10% drug content and particle size was found to be 23.74± 0.35µm with spherical shaped free flowing particles. In vitro release was carried out using dissolution apparatus in 0.1N HCl and optimized formulation shows 96.06 ± 0.54 % drug release within 8 hrs. which follows quasi-fickian type of transport and was characterized by the Korsmeyer- Peppas model. Formulation was stable at 5 oC ± 3 oC for two months. Developed liposphere formulation was able to sustain the drug release and entrap the pioglitazone hydrochloride drug at high level.


Keyword:     Pioglitazone hydrochloride lipospherescompritol® 888 ATO melt dispersion technique factorial design.


Citation:

Bhosale UM, Galgatte UC, Chaudhari PD. Development of pioglitazone hydrochloride lipospheres by melt dispersion technique: Optimization and evaluation. J App Pharm Sci, 2016; 6 (01): 107-117.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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