Research Article | Volume: 6, Issue: 1, January, 2016

Anti-infective Activities of Secondary Metabolites from Vitex pinnata

Nurkhalida Kamal ,  Carol Clements,  Alexander I. Gray,  RuAngelie Edrada-Ebel   
Nurkhalida Kamal1 & 2, Carol Clements1, Alexander I. Gray1, RuAngelie Edrada-Ebel1

1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom.

2Faculty of Bioresources & Food Industry, Universiti Sultan Zainal Abidin, Kampus Tembila, 22200 Besut, Terengganu, Malaysia.

Open Access   

Published:  Jan 26, 2016

DOI: 10.7324/JAPS.2016.600117
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Abstract

The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids β-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5-hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.


Keyword:     Vitex pinnata steroids flavones antitrypanosomal activity anti-mycobacterial activity.

Citation:

Kamal N, Clements C, Gray AI, Edrada-Ebel R. Anti-infective Activities of Secondary Metabolites from Vitex pinnata. J App Pharm Sci, 2016; 6 (01): 102-106.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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