Research Article | Volume: 6, Issue: 1, January, 2016

Triterpenoid fraction isolated from Euphorbia tirucalli Linn. ameliorates collagen induced arthritis in Wistar rats

Pramod Chandrasenan M. V. Neethu V. M. Anjumol Vysakh Anandan Raj Selvaraj   

Open Access   

Published:  Jan 26, 2016

DOI: 10.7324/JAPS.2016.600112
Abstract

The present study evaluates the anti arthritic efficacy of triterpenoid fraction isolated from Eurphobia tirucalli Linn. (TET) in collagen induced arthritis model (CIA). TET at a dose of 100 and 200 mg /kg p.o was tested in CIA induced animals. The degree of inflammation was evaluated by hind paw swelling, arthritic index, body weight and hematological parameters. Radiological and histopathological evaluations of ankle joints were also studied. Oral administration of TET (200 mg/kg) exhibited significant (p<0.05) anti arthritic activity by decreasing the paw volume, normal body weight gain as compared to CIA groups. The altered hematological parameters like C-reactive protein (CRP) and white blood cells level in CIA groups were bring back to near normal in TET (200 mg/kg) treatment group. Further radiological and histopathological studies revealed the anti arthritic activity by indicating remodeling of ankle joints in TET treated groups. The results were parallel with standard drug diclofenac (5 mg/kg). Taken together findings from the current investigation suggest that TET has beneficial anti arthritic effect by reversing the pathological condition in a significant manner.


Keyword:     Eurphobia. tirucalli collagen arthritis inflammation paw swelling C-reactive protein.


Citation:

Chandrasenan P, Neethu MV, Anjumol VM, Anandan V, Selvaraj R. Triterpenoid fraction isolated from Euphorbia tirucalli Linn. ameliorates collagen induced arthritis in Wistar rats. J App Pharm Sci, 2016; 6 (01): 070-075.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
349 Views 48 Downloads 397 Total

Year

Month

Related Search

By author names