Mini Review | Volume: 5, Issue: 12, December, 2015

Role of oxidative stress in opiate withdrawal and dependence: Exploring the potential use of honey

Nor Hidayah Abu Bakar Siti Norhajah Hashim Nasir Mohamad Rohayah Husain Liyana Hazwani Mohd Adnan Halim Shariff Nur Husna Zakaria   

Open Access   

Published:  Dec 27, 2015

DOI: 10.7324/JAPS.2015.501228

Opiate dependence and withdrawal is a worldwide public health problem and give a significant burden to society. In exploring the problems of opiate dependence and withdrawal, oxidative stress in thought to be involved in the mechanism of the development of dependence and tolerance to morphine. Therefore, there is possibility that antioxidant has the role to reduce the oxidative stress leading to opiate dependence and withdrawal. In this mini review we describe the evidence of relationship between oxidative stress and opiate dependence. We also describe the evidence of honey which has been claimed to have high antioxidant properties and its promising potential to reduce oxidative stress in opiates dependence and tolerance individuals.

Keyword:     Opiate dependence and withdrawal antioxidant oxidative stress honey.


Abu Bakar NH, Hashim SN, Mohamad N, Husain R, Adnan LHM, Shariff H, Zakaria NH. Role of oxidative stress in opiate withdrawal and dependence: Exploring the potential use of honey. J App Pharm Sci, 2015; 5 (12): 159-161.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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