Research Article | Volume: 5, Issue: 11, November, 2015

Anti-inflammatory and analgesic activities of methanol extracts of stem bark of Anthocleista djalonensis in wistar rats

Olusayo Aderonke Shorinwa Adaora Obiageli Enemuoh Fidelia Ijeoma Uche   

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501120
Abstract

This study was carried out to evaluate the anti-inflammatory and analgesic activities of the stem bark extract in albino rats. Evaluation of the anti-inflammatory activity was done using fresh egg albumin induced rat paw edema with a plethysmometer, while the analgesic effect was determined using the analgesymeter mechanically induced pain. The methanolic extract of the stem bark of Anthocleista djalonensis was evaluated at 100mg/kg, 200mg/kg, and 400mg/kg through the oral route. Indomethacin (10mg/kg) was used as standard reference anti-inflammatory and analgesic drug. Preliminary phytochemical screening showed the presence of tannins, flavonoids, saponins and deoxysugars. The different doses of the extract significantly inhibited the egg albumin induced inflammation (P<0.05) in a non-dose dependent manner. The extract also significantly inhibited the pain (P<0.05) mechanically induced on the rat paw by the analgesymeter. The findings of this study showed that the plant possess significant anti-inflammatory and analgesic activities.


Keyword:     Anthocleista djalonensis anti-inflammatory analgesic analgesymeter plethysmometer.


Citation:

Olusayo Aderonke Shorinwa, Adaora Obiageli Enemuoh, Fidelia Ijeoma Uche. Anti-inflammatory and analgesic activities of methanol extracts of stem bark of Anthocleista djalonensis in wistar rats. J App Pharm Sci, 2015; 5 (11): 117-120.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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