Published:  Nov 27, 2015DOI: 10.7324/JAPS.2015.501120
This study was carried out to evaluate the anti-inflammatory and analgesic activities of the stem bark extract in albino rats. Evaluation of the anti-inflammatory activity was done using fresh egg albumin induced rat paw edema with a plethysmometer, while the analgesic effect was determined using the analgesymeter mechanically induced pain. The methanolic extract of the stem bark of Anthocleista djalonensis was evaluated at 100mg/kg, 200mg/kg, and 400mg/kg through the oral route. Indomethacin (10mg/kg) was used as standard reference anti-inflammatory and analgesic drug. Preliminary phytochemical screening showed the presence of tannins, flavonoids, saponins and deoxysugars. The different doses of the extract significantly inhibited the egg albumin induced inflammation (P<0.05) in a non-dose dependent manner. The extract also significantly inhibited the pain (P<0.05) mechanically induced on the rat paw by the analgesymeter. The findings of this study showed that the plant possess significant anti-inflammatory and analgesic activities.
Olusayo Aderonke Shorinwa, Adaora Obiageli Enemuoh, Fidelia Ijeoma Uche. Anti-inflammatory and analgesic activities of methanol extracts of stem bark of Anthocleista djalonensis in wistar rats. J App Pharm Sci, 2015; 5 (11): 117-120.
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