Research Article | Volume: 5, Issue: 11, November, 2015

Anti-inflammatory and analgesic activities of methanol extracts of stem bark of Anthocleista djalonensis in wistar rats

Olusayo Aderonke Shorinwa Adaora Obiageli Enemuoh Fidelia Ijeoma Uche   

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501120
Abstract

This study was carried out to evaluate the anti-inflammatory and analgesic activities of the stem bark extract in albino rats. Evaluation of the anti-inflammatory activity was done using fresh egg albumin induced rat paw edema with a plethysmometer, while the analgesic effect was determined using the analgesymeter mechanically induced pain. The methanolic extract of the stem bark of Anthocleista djalonensis was evaluated at 100mg/kg, 200mg/kg, and 400mg/kg through the oral route. Indomethacin (10mg/kg) was used as standard reference anti-inflammatory and analgesic drug. Preliminary phytochemical screening showed the presence of tannins, flavonoids, saponins and deoxysugars. The different doses of the extract significantly inhibited the egg albumin induced inflammation (P<0.05) in a non-dose dependent manner. The extract also significantly inhibited the pain (P<0.05) mechanically induced on the rat paw by the analgesymeter. The findings of this study showed that the plant possess significant anti-inflammatory and analgesic activities.


Keyword:     Anthocleista djalonensis anti-inflammatory analgesic analgesymeter plethysmometer.


Citation:

Olusayo Aderonke Shorinwa, Adaora Obiageli Enemuoh, Fidelia Ijeoma Uche. Anti-inflammatory and analgesic activities of methanol extracts of stem bark of Anthocleista djalonensis in wistar rats. J App Pharm Sci, 2015; 5 (11): 117-120.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
386 Views 18 Downloads 404 Total

Year

Month

Related Search

By author names