Research Article | Volume: 5, Issue: 9, September, 2015

Antioxidant and tyrosinase inhibition activities of α- mangostin and Garcinia mangostana Linn. pericarp extracts

Wan Nur Atiqah Wan Hassan Razauden Mohamed Zulkifli Norazah Basar Farediah Ahmad Mohd Azizi Che Yunus   

Open Access   

Published:  Sep 27, 2015

DOI: 10.7324/JAPS.2015.50907

The methanol, ethyl acetate and petroleum ether crude extracts of mangosteen pericarp and α- mangostin were evaluated for the antioxidant capacity and tyrosinase inhibition properties. The ferric reducing antioxidant power (FRAP) assay was used to investigate their antioxidant capacity. Tyrosinase inhibition effect was evaluated using mushroom tyrosinase inhibition assay. Methanol extract has higher antioxidant reducing capacity (m= 1.621), compared to the rest of the extracts. Meanwhile, ethyl acetate extract and α- mangostin showed potent tyrosinase inhibition activities as compared to Kojic acid, a well- known tyrosinase inhibitor. It is observed that tyrosinase inhibition effect is antioxidant independent as ethyl acetate extract possessed low antioxidant capacity. This study suggests direct tyrosinase inhibition by ethyl acetate extract of Garcinia mangostana.

Keyword:     Garcinia mangostana Linn. α-mangostin xanthone antioxidant tyrosinase inhibition.


Wan Nur Atiqah Wan Hassan, Razauden Mohamed Zulkifli, Norazah Basar, Mohd Azizi Che Yunus, Farediah Ahmad. Antioxidant and tyrosi.nase inhibition activities of α- mangostin and Garcinia mangostana Linn. pericarp extracts. J App Pharm Sci, 2015; 5 (09): 037-040.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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