Research Article | Volume: 5, Issue: 8, August, 2015

Antioxidant and tyrosinase inhibition activities of Eurycoma longifolia and Swietenia macrophylla

Wan Nur Atiqah Wan Hassan,  Razauden Mohamed Zulkifli,  Farediah Ahmad,  Mohd Azizi Che Yunus   
Wan Nur Atiqah Wan Hassan1, Razauden Mohamed Zulkifli1, Farediah Ahmad2, Mohd Azizi Che Yunus3

1Department of Bioscience and Health Sciences, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

2Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

3Department of Chemical Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

Open Access   

Published:  Aug 28, 2015

DOI: 10.7324/JAPS.2015.50802
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Abstract

Extract from plants have been reported to contain valuable bioactive compounds that have potential in promoting antioxidant activity. The present study was aimed to investigate the extracts of two plants available in Southeast Asia, Eurycoma longifolia and Swietenia macrophylla for their primary metabolite contents, phenolic contents, antioxidant and anti- tyrosinase activity. Two types of solvents were utilised in the extraction process of both plants. Ethyl acetate found to be a better solvent for isolation of primary metabolite compound compared to methanol. For Folin-Ciocalteu assay, methanol extract of Swietenia macrophylla possed higher phenolic content while for Eurycoma longifolia, ethyl acetate extract had higher phenolic content. In DPPH assay, the radical scavenging activity of extracts were strongly correlated to the total phenolic content based on the percentage of DPPH radical scavenging of each extracts (p<0.05). In tyrosinase inhibition assay, the activity of each extracts were very low compared to standard Kojic acid. It was assumed that, the ability of plant extracts to inhibit tyrosinase are partly contributed by antioxidant potential of the extracts (p<0.01).


Keyword:     Eurycoma longifolia Swietenia macrophylla phenolic content antioxidant tyrosinase inhibition.

Citation:

Wan Nur Atiqah Wan Hassan, Farediah Ahmad, Razauden Mohamed Zulkifli, Mohd Azizi Che Yunus. Antioxidant and tyrosinase inhibition activities of Eurycoma longifolia and Swietenia macrophylla. J App Pharm Sci, 2015; 5 (08): 006-010.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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