Research Article | Volume: 5, Issue: 5, May, 2015

Phytochemical screening and evaluation of analgesic, anti-inflammatory activities of Peganum harmala Linn., seeds in rodents

M. R. Pradeep Kumar Shrinivas D. Joshi V. H. Kulkarni Chetan Savant   

Open Access   

Published:  May 27, 2015

DOI: 10.7324/JAPS.2015.50510
Abstract

The objective of this research work is to carryout the phytochemical screening and evaluate the analgesic, anti-inflammatory activities of Peganum harmala Linn., seeds. In this study different extracts of Peganum harmala (Linn) seeds were evaluated for analgesic and anti-inflammatory activities using glacial acetic acid induced writhing and carrageenan induced rat paw edema models respectively. For analgesic and anti-inflammatory activities aspirin and diclofenac were used as standard drugs respectively. The ethyl acetate extract showed significant analgesic and anti-inflammatory activities, thus it can be considered as a potential candidate for analgesic and antiinflammatory activities. The presence of alkaloids, steroids, flavonoids in ethyl acetate extract of Peganum harmala (Linn) seeds could be attributed for the claimed analgesic and anti-inflammatory activities.


Keyword:     Peganum harmala Zygophyllaceae analgesic anti-inflammatory carrageenan.


Citation:

Pradeep Kumar M.R., Joshi S.D., Kulkarni V.H., Chetan Savant. Phytochemical screening and evaluation of analgesic, antiinflammatory activities of Peganum harmala Linn. seeds in rodents. J App Pharm Sci, 2015; 5 (05): 052-055.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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