Research Article | Volume: 5, Issue: 2, February, 2015

Analysis of chemical composition and its analgesic and anti-inflammatory activity of essential oil of sintoc bark (Cinnamomum sintoc bl.) using in vivo methods

Sri Adi Sumiwi Anas Subarnas Supriyatna Supriyatna Marline Abdasah Muchtaridi Muchtaridi   

Open Access   

Published:  Feb 27, 2015

DOI: 10.7324/JAPS.2015.50209

Sintoc bark (Cinnamomum sintoc Bl) belongs to Lauraceae (the laurel family). It has been used empirically for a treatment for swelling caused by insects’ bites. In this study, the research examined the analgesic activity and anti-inflammation of essential oil of sintocbark using in vivo methods. The mechanism of anti-inflammation was predicted using molecular docking against COX-2. Essential oil of sintoc bark was collected by distilling through steam distillation, and then analyzed by GC-MS. Analgesic and anti-inflammatory activity was examined by in vivo, which were conducted by writhing and carrageenan-induced methods, respectively. The findings showed that the tested sintoc bark oils contained 36 components of essential oil with eugenol (38.38 %) as a major compound. In the in vivo experiments, sintoc bark oils with doses 0.005 mL, 0.010 mL, and 0.020 mL/20g body weight significantly (p<0.05) reduced the number of writhing of mice when compared to negative control group. All of doses of sintoc bark oils gave significantly affect (confidence level 99 %) compare to negative control. Sintoc oil with dose 0.2 ml/200g had the strongest inhibition compare to positive control (indometasin 10 mg/kg body weight). The molecular docking results indicated that the compounds of aryl propanoid were generally potential to inhibit COX-2.

Keyword:     Sintoc bark oils eugenol analgesic anti-inflammatory.


Sri Adi Sumiwi, Anas Subarnas, Supriyatna Supriyatna, Marline Abdasah, Muchtaridi Muchtaridi. Analysis of Chemical Composition and its Analgesic and Anti-Inflammatory Acitvity of Essential oil of Sintoc Bark (Cinnamomum sintocbl.) Using in vivo Methods. J App Pharm Sci, 2015; 5 (02): 058-065.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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