Research Article | Volume: 4; Issue: 9, September, 2014

Development and In-vitro evaluation of poly (lactic acid) films for controlled release studies of Lapatinib: an anticancer drug

Chandra Babu Allu Sudhakar Poluru Siraj Shaik Subha MCS Chowdoji Rao Kashayi   

Open Access   

Published:  Sep 27, 2014

DOI: 10.7324/JAPS.2014.40904
Abstract

Biodegradable poly (lactic acid) films containing Lapatinib were prepared by spreading polymer / Lapatinib solution on the non-solvent surface. Different drug loading polymer films can be obtained by controlling the weight ratios of drug and polymer. The synthesized Lapatinib loaded PLA films were evaluated by different parameters such as drug loading, encapsulation efficiency, surface morphology, differential scanning calorimetry, powder X-ray diffractometry and In vitro drug release kinetics. Various combinations of the polymer-drug weight ratios were used to achieve In vitro release of drug over a period of 30-35 days, with initial burst release


Keyword:     poly (lactic acid)Lapatinibfilmsbiodegradablecontrolled release.


Citation:

Chandra Babu Allu, Sudhakar Poluru, Siraj Shaik, Subha MCS, Chowdoji Rao Kashayi. Development and In-vitro evaluation of poly (lactic acid) films for controlled release studies of Lapatinib: an anticancer drug. J App Pharm Sci, 2014; 4 (09): 022-026.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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