Research Article | Volume: 4, Issue: 5, May, 2014

Studies on the Prodigiosin Production from Streptomyces coelicolor in Liquid Media by Using Heated Lactobacillus rhamnosus

Huy NA Do and Tu H K Nguyen   

Open Access   

Published:  May 27, 2014

DOI: 10.7324/JAPS.2014.40504
Abstract

Prodigiosin (PG) is not only an antibiotic but it has also been characterized immunosuppressive and anticancer activities. Prodigiosin is produced by Streptomyces coelicolor and Seratia marcescens. In this study, prodigiosin (PG) production of S. coelicolor was optimized using 50µL, 100µL of heated cells at 70oC and 100oC of Lactobacillus rhamnosus. With 50µL heat-killed cells at 70oC L. rhamnosus, prodigiosin (PG) production of S. coelicolor enhanced the maximum prodigiosin concentration (9.79 ± 1.68 mg/L) by six-fold at the early stage in the second day incubation in the comparison with prodigiosin (PG) production of S. coelicolor without heated L. rhamnosus (1.43 ± 0.22 mg/L). There were the affects of the components of L. rhamnosus on PG production. This is the first report that L. rhamnosus affecting on PG production in S. coelicolor.


Keyword:     Lactobacillus rhamnosus prodigiosin Streptomyces coelicolor.


Citation:

Huy NA Do, Tu H K Nguyen., Studies on the Prodigiosin Production from Streptomyces Coelicolor in Liquid Media by Using Heated Lactobacillus Rhamnosus. J App Pharm Sci, 2014; 4 (05): 021-024.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
647 Views 24 Downloads 671 Total

Year

Month

Related Search

By author names